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DMAPT

Product Name
DMAPT
CAS No.
870677-05-7
Chemical Name
DMAPT
Synonyms
DMAPT;DMAPT, 10 mM in DMSO;DMAPT, NF-kappaB inhibitor;Dimethylamino Parthenolide;UJNSFDHVIBGEJZ-KVUCBBCISA-N;NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB;(1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one;Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-
CBNumber
CB62627768
Molecular Formula
C17H27NO3
Formula Weight
293.4
MOL File
870677-05-7.mol
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DMAPT Property

storage temp. 
-20°C
solubility 
Soluble in DMSO, Ethyl acetate, or Ethanol.
form 
solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month.
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Safety

HS Code 
2932209090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20436
Product name
Dimethylamino Parthenolide
Purity
≥99%
Packaging
10mg
Price
$115
Updated
2022/04/27
Cayman Chemical
Product number
20436
Product name
Dimethylamino Parthenolide
Purity
≥99%
Packaging
25mg
Price
$242
Updated
2022/04/27
Biosynth Carbosynth
Product number
BD162719
Product name
Dimethylamino parthenolide
Packaging
50mg
Price
$250
Updated
2021/12/16
AK Scientific
Product number
7347EJ
Product name
Dmapt
Packaging
25mg
Price
$401
Updated
2021/12/16
Biosynth Carbosynth
Product number
BD162719
Product name
Dimethylamino parthenolide
Packaging
25mg
Price
$150
Updated
2021/12/16
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DMAPT Chemical Properties,Usage,Production

Description

DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2

Uses

DMAPT is a parthenolide derivative that functions as an antileukemic and cytotoxic agents.

in vivo

Treatment with DMAPT (100 mg/kg, Oral gavage daily for 7 days) increases sensitivity of PC-3 tumor xenografts to X-rays[2].
DMAPT (100 mg/kg, Oral gavage thrice weekly from 42 to 300 days since birth) treatment slows normal tumor development in TRAMP mice, extending the time-to-palpable prostate tumor by 20%[3].
DMAPT further reduces the metastatic area below that of the water vehicle treatment group in lung tissues (0.10% ± 0.15 SD, 92% reduction, p = 0.0028) in TRAMP mice[3].

References

[1] RAJASUBRAMANIAM SHANMUGAM. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species†[J]. International Journal of Cancer, 2010, 128 10: 2481-2494. DOI:10.1002/ijc.25587
[2] NEIL C. ESTABROOK . Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays[J]. Free Radical Biology and Medicine, 2011, 51 12: Pages 2249-2258. DOI:10.1016/j.freeradbiomed.2011.09.029

DMAPT Preparation Products And Raw materials

Raw materials

Preparation Products

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DMAPT Suppliers

CHINA 23 United Kingdom 1 United States 6 Global 30
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19654
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

870677-05-7, DMAPTRelated Search:

ZM 447439 Ko 143 LFM-A13 Cantharidin

  • (1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one
  • DMAPT
  • UJNSFDHVIBGEJZ-KVUCBBCISA-N
  • Dimethylamino Parthenolide
  • Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-
  • NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB
  • DMAPT, NF-kappaB inhibitor
  • DMAPT, 10 mM in DMSO
  • 870677-05-7