INCB8761(PF-4136309)

ChemicalBook > CAS DataBase List > INCB8761(PF-4136309)

Product Name: INCB8761(PF-4136309)
CAS No.: 1341224-83-6
Chemical Name: INCB8761(PF-4136309)
Synonyms: CS-1440;EOS-61910;NCB8761(PF-4136309);INCB8761(PF-4136309);PF-04136309(INCB-8761);ZNSVOHSYDRPBGI-LXWOLXCRSA-N;N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL);INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761;INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309;N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
CBNumber: CB62627975
Molecular Formula: C29H31F3N6O3
Formula Weight: 568.59
MOL File: 1341224-83-6.mol

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INCB8761(PF-4136309) Property

Boiling point:: 712.2±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml)
pka: 13.17±0.46(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21965
Product name: INCB 8761
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21965
Product name: INCB 8761
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21965
Product name: INCB 8761
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 21965
Product name: INCB 8761
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-0610
Product name: PF-4136309
Purity: 99.59%
Packaging: 100mg
Price: $760
Updated: 2021/12/16

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INCB8761(PF-4136309) Chemical Properties,Usage,Production

Description

PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC₅₀s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively). It also inhibits the voltage-gated potassium channel subtype K_v11.1 by 35% when used at a concentration of 10 μM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC₅₀ value of 3.9 nM.

Uses

PF 4136309 is a CCR5 receptor antagonists that contributes to the treatment of rheumatoid arthritis.

References

1) Chu-Biao?et al.?(2011),?Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist;?ACS Med. Chem. Lett.?2?913 2) Sanford?et al.?(2013),?Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis;?Clin. Cancer Res.?19?3404 3) Nywenig?et al.?(2016),?Phase 1b study targeting tumor associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer;?Lancet Oncol.?17?651

INCB8761(PF-4136309) Preparation Products And Raw materials

Raw materials

Preparation Products

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1341224-83-6, INCB8761(PF-4136309)Related Search:

Adapalene Vorinostat (+)-Camptothecin 17-AAG

INCB8761(PF-4136309)

NCB8761(PF-4136309)

PF-04136309(INCB-8761)

Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-

EOS-61910

N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide

ZNSVOHSYDRPBGI-LXWOLXCRSA-N

N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL)

CS-1440

INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761

N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide

INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309

1341224-83-6