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KG5

Product Name
KG5
CAS No.
877874-85-6
Chemical Name
KG5
Synonyms
KG5;KG5, 10 mM in DMSO;2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine;2-(Methylthio)-6-(4-(5-((3-(trifluoromethyl)phenyl)amino)-4H-1,2,4-triazol-3-yl)phenoxy)pyrimidin-4-amine;2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine;4-Pyrimidinamine, 2-(methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-;B-Raf,antiangiogenic,KIT,c-Kit,KG5,CD135,Raf kinases,Raf,PDGFR,Cluster of differentiation antigen 135,Platelet-derived growth factor receptor,Fms like tyrosine kinase 3,metastasis,c-Raf,FLT3,PDGFRβ,inhibit,anticancer,phosphorylation,SCFR,Inhibitor,KG 5,CD117,KG-5
CBNumber
CB62628008
Molecular Formula
C20H16F3N7OS
Formula Weight
459.45
MOL File
877874-85-6.mol
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KG5 Property

Boiling point:
654.0±65.0 °C(Predicted)
Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
9.54±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5260
Product name
KG5
Purity
≥98%(HPLC)
Packaging
10
Price
$208
Updated
2021/12/16
Tocris
Product number
5260
Product name
KG5
Purity
≥98%(HPLC)
Packaging
50
Price
$870
Updated
2021/12/16
TRC
Product number
K427985
Product name
KG5
Packaging
10mg
Price
$195
Updated
2021/12/16
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KG5 Chemical Properties,Usage,Production

Uses

KG 5 is orally active drug that stabilizes inactive state of PDGFRβ/B-RAF and inhibits tumor angiogenesis.

in vivo

KG5 (Compound 6; 100 mg/kg; oral administration; daily; for 26 days) treatment prevents tumor growth in an orthotopic renal cell carcinoma model[1].
KG5 (Compound 6; 50 mg/kg; i.p.; twice daily) treatment completely blocks angiogenesis relative to vehicle control in mice (injected with Matrigel containing bFGF). Pharmacokinetic analysis of the dose and formulation of KG5 used indicated a Cmax of 3.6 μg/mL, T1/2 of 11.5 h, and an area under the concentration time curve (AUC0-12h) of 14.7 μg?h/mL[1].
KG5 (Compound 6; 1 μM) disrupts a late step in angiogenesis during zebrafish embryogenesis[1].

Animal Model:Male Nu/Nu mice injected with SN12C-RFP cells[1]
Dosage:100 mg/kg
Administration:Oral administration; daily; for 26 days
Result:Prevented tumor growth in an orthotopic renal cell carcinoma model.

IC 50

B-Raf; PDGFRβ: 520 nM (Kd); FLT3: 52 nM (Kd); KIT: 170 nM (Kd); PDGFRα: 300 nM (Kd); c-Raf

storage

Store at -20°C

KG5 Preparation Products And Raw materials

Raw materials

Preparation Products

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KG5 Suppliers

China 26 United Kingdom 1 United States 4 USA 1 Global 32
Shanghai Beckham Medical Technology Co., Ltd
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877874-85-6, KG5Related Search:


  • KG5
  • 2-methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine
  • 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
  • 4-Pyrimidinamine, 2-(methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-
  • B-Raf,antiangiogenic,KIT,c-Kit,KG5,CD135,Raf kinases,Raf,PDGFR,Cluster of differentiation antigen 135,Platelet-derived growth factor receptor,Fms like tyrosine kinase 3,metastasis,c-Raf,FLT3,PDGFRβ,inhibit,anticancer,phosphorylation,SCFR,Inhibitor,KG 5,CD117,KG-5
  • 2-(Methylthio)-6-(4-(5-((3-(trifluoromethyl)phenyl)amino)-4H-1,2,4-triazol-3-yl)phenoxy)pyrimidin-4-amine
  • KG5, 10 mM in DMSO
  • 877874-85-6