ChemicalBook > CAS DataBase List > MB-05032

MB-05032

Product Name
MB-05032
CAS No.
261365-11-1
Chemical Name
MB-05032
Synonyms
MB-05032;MB-05032; MB05032;2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole;[5-(2-Amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid;P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid;Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-
CBNumber
CB62628073
Molecular Formula
C11H15N2O4PS
Formula Weight
302.29
MOL File
261365-11-1.mol
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MB-05032 Property

Boiling point:
576.7±60.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
0.98±0.10(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3207
Product name
MB05032
Purity
≥98% (HPLC)
Packaging
5MG
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3207
Product name
MB05032
Purity
≥98% (HPLC)
Packaging
25MG
Price
$323
Updated
2024/03/01
Tocris
Product number
6618
Product name
MB05032
Purity
≥98%(HPLC)
Packaging
10
Price
$212
Updated
2021/12/16
Tocris
Product number
6618
Product name
MB05032
Purity
≥98%(HPLC)
Packaging
50
Price
$891
Updated
2021/12/16
ChemScene
Product number
CS-1552
Product name
MB05032
Purity
99.69%
Packaging
50mg
Price
$960
Updated
2021/12/16
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MB-05032 Chemical Properties,Usage,Production

Biological Activity

mb05032 is a potent and selective gng inhibitor targeted the amp binding site of fructose 1,6-bisphosphatase (fbpase) with an ic50 value of 16 nm [1].gluconeogenesis (gng) is a metabolic pathway which could result in the generation of glucose from certain non-carbohydratecarbon substrates.

in vitro

mb06322 inhibited glucose synthesis by human hepatocytes over a narrow concentration range with full inhibition achieved at 1 μm in a concentration-dependent manner [2]. mb05032 inhibited human liver fbpase with a potency (ic50 of 16 ± 1.5 nm) significantly greater than the natural inhibitor, amp (ic50 of 1 μm), and the most well characterized amp mimetic, zmp (ic50of 12 ± 1.4 μm). mb05032 inhibited rat fbpase 3-fold weaker (ic50 of 61 ± 4 nm) than human fbpase, whereas amp was 20-fold weaker as an inhibitor [1]. in islet β-cells,inhibition of fbpase activity by mb05032 led to a significant increase of their glucose utilization and cellular atp to adp ratios and consequently enhanced gsis in vitro [2].

in vivo

in male zdf rats, oral administration of mb06322 resulted in dose-dependent inhibition of [14c]bicarbonate incorporation into glucose. maximal gng inhibition (≈80%) is achieved at 100–300 mg/kg mb06322. in mb06322-treated rats, intermediates upstream of fbpase were elevated 1.5- to 3.1-fold relative to vehicle-treated mice. mb06322 treatment also resulted in elevated lactate levels (79%) only in aged zdf rats. [2]. oral administration of mb06322 to young (8–9 weeks old) zdf rats with mild diabetes (basal insulin levels of 7.7 ± 0.7 ng/ml) and aged (12–13 weeks) zdf rats with overt diabetes (basal insulin levels of 0.65 ± 0.16 ng/ml) lowered the level of glucose in a dose-dependent manner [1]. the dose–dependent response is relatively steep, with 6–10 mg/kg and 30–100 mg/kg being the approximate doses associated with minimal and maximal activity, respectively. after drug administration 2.5–5 h, glucose lowering occurs rapidly with maximal effects [1].

target

IC50: 16 nM (Human Liver FBPase)

storage

Store at -20°C

References

[1] erion m d, van poelje p d, dang q, et al. mb06322 (cs-917): a potent and selective inhibitor of fructose 1, 6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes[j]. proceedings of the national academy of sciences, 2005, 102(22): 7970-7975.
[2] zhang y, xie z, zhou g, et al. fructose-1, 6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic β-cells[j]. endocrinology, 2010, 151(10): 4688-4695.

MB-05032 Preparation Products And Raw materials

Raw materials

Preparation Products

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MB-05032 Suppliers

Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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SPIRO PHARMA
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eric_feng1954@126.com
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China
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Codow Chemical Co.,Ltd.
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18620099427
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+86-20-62619665
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amy@howeipharm.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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China
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Guangzhou QiYun Biotechnology Co., Ltd.
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020-61288194 61288195
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020-61288700
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505721671@qq.com
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China
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Chengdu Dianchun Technology Co., Ltd
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400-1166-196 18502815961
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cdhxsj@163.com
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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United States
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Taizhou Crene Biotechnology Co. Ltd.
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+86-0576-88813233 +86-13396860566
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sales@pharm-intermediates.com
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China
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1991
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261365-11-1, MB-05032Related Search:


  • MB-05032
  • 2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole
  • [5-(2-Amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]phosphonic acid
  • MB-05032; MB05032
  • P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
  • Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-
  • 261365-11-1