ChemicalBook > CAS DataBase List > MK-6892

MK-6892

Product Name
MK-6892
CAS No.
917910-45-3
Chemical Name
MK-6892
Synonyms
MK-6892;CS-2425;MK 6892;MK6892;HCAR2,PUMA-G,MK-6892,HM74A,HCA2,Inhibitor,GPR109A,MK6892,inhibit,MK 6892;2-(3-(3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)-2,2-dimethylpropanamido)cyclohex-1-ene-1-carboxylic acid;2-[[3-[3-(5-Hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-1-cyclohexene-1-carboxylic acid;1-Cyclohexene-1-carboxylic acid, 2-[[3-[3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-
CBNumber
CB62628149
Molecular Formula
C19H22N4O5
Formula Weight
386.4
MOL File
917910-45-3.mol
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MK-6892 Property

storage temp. 
Store at -20°C
solubility 
≥34.9 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with ultrasonic; insoluble in H2O
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-1480
Product name
MK-6892
Purity
99.43%
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-1480
Product name
MK-6892
Purity
99.43%
Packaging
10mg
Price
$456
Updated
2021/12/16
ApexBio Technology
Product number
A3623
Product name
MK-6892
Packaging
10mg
Price
$557
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014020
Product name
MK-6892
Purity
95.00%
Packaging
0.1G
Price
$723
Updated
2021/12/16
ChemScene
Product number
CS-1480
Product name
MK-6892
Purity
99.43%
Packaging
50mg
Price
$1080
Updated
2021/12/16
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MK-6892 Chemical Properties,Usage,Production

Biological Activity

mk-6892 is a highly potential gpr109a agonists.

in vitro

despite the increased serum shift of these compounds, the representative 1e was highly potent. furthermore, these compounds had no activity on gpr109b and gpr81, the two most closely related gpcrs with 96% and 50% sequence identity to gpr109a,respectively [1].

in vivo

na or mk-6892 was orally administered to wt or na receptor null mice on the same c57bl/6 genetic background. after 15 min of 100 mpk dosing of na or mk-6892 to fed wt or na receptor null mice, the blood levels of mk-6892 at 15 min were 229 μm (950-fold greater than the in vitro ec50 determined in mouse na receptor gtpγs assay, which is 240 nm) in wt mice and 148 μm (620-fold greater than the in vitro ec50) in na receptor null mice [1].

IC 50

ic50 value: 4.0 nm (ki for human gpr109a) [1]

MK-6892 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-6892 Suppliers

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917910-45-3, MK-6892Related Search:


  • MK-6892
  • 2-[[3-[3-(5-Hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-1-cyclohexene-1-carboxylic acid
  • MK 6892;MK6892
  • CS-2425
  • 1-Cyclohexene-1-carboxylic acid, 2-[[3-[3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-
  • HCAR2,PUMA-G,MK-6892,HM74A,HCA2,Inhibitor,GPR109A,MK6892,inhibit,MK 6892
  • 2-(3-(3-(5-Hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)-2,2-dimethylpropanamido)cyclohex-1-ene-1-carboxylic acid
  • 917910-45-3