NBI-74330

Product Name: NBI-74330
CAS No.: 855527-92-3
Chemical Name: NBI-74330
Synonyms: NBI-74330;N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide;(R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acetamide;Benzeneacetamide, N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)-
CBNumber: CB62628189
Molecular Formula: C32H27F4N5O3
Formula Weight: 605.58
MOL File: 855527-92-3.mol

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NBI-74330 Property

Boiling point:: 752.5±70.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:100.0(Max Conc. mg/mL);165.1(Max Conc. mM)
pka: 4?+-.0.11(Predicted)
form: Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28442
Product name: NBI 74330
Packaging: 1mg
Price: $359
Updated: 2024/03/01

Cayman Chemical

Product number: 28442
Product name: NBI 74330
Packaging: 5mg
Price: $1253
Updated: 2024/03/01

ChemScene

Product number: CS-2217
Product name: NBI-74330
Purity: 99.23%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

ChemScene

Product number: CS-2217
Product name: NBI-74330
Purity: 99.23%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-2217
Product name: NBI-74330
Purity: 99.23%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

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NBI-74330 Chemical Properties,Usage,Production

Description

NBI 74330 is a chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist (K_i = 3.6 nM in a radioligand binding assay). It inhibits calcium mobilization induced by chemokine (C-X-C motif) ligand 10 (CXCL10) or CXCL11 in RBL cells expressing human CXCR3 (IC₅₀ = 7 nM for both). NBI 74330 inhibits CXCL11-induced chemotaxis of CXCR3-expressing H9 cells and PHA and IL-2 differentiated T cells (IC₅₀s = 3.9 and 6.6 nM, respectively). In vivo, NBI 74330 (100 mg/kg) reduces peritoneal lymphocyte migration in a mouse model of peritonitis. It reduces the size and number of aortic arch atherosclerotic lesions in Ldlr^-/- mice. NBI 74330 reduces spinal cord microglial activation and levels of CXCL4, CXCL9, and CXCL10 and decreases thermal and mechanical hyperalgesia in a rat model of chronic constriction injury-induced neuropathic pain.

Uses

N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide is a CXCR3 antagonist.

NBI-74330 Preparation Products And Raw materials

Raw materials

Preparation Products

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NBI-74330 Suppliers

China 27 United States 7 Global 34

Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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Guangzhou QiYun Biotechnology Co., Ltd.

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Musechem

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Absin Bioscience Inc.

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855527-92-3, NBI-74330Related Search:

(2R,3S/2S,3R)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUORO-4-PYRIMIDINYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL N-ACETYLLACTOSAMINE Sulfanilamide 2-Ethoxyethanol

NBI-74330

N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide

Benzeneacetamide, N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)-

(R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(pyridin-3-ylmethyl)acetamide

855527-92-3

C32H27F4N5O3