Poloxipan
- Product Name
- Poloxipan
- CAS No.
- 1239513-63-3
- Chemical Name
- Poloxipan
- Synonyms
- Poloxipan;7H-Thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione, 2-[(5-bromo-2-methoxyphenyl)methylene]-6-methyl-, (2Z)-
- CBNumber
- CB62628275
- Molecular Formula
- C14H10BrN3O3S
- Formula Weight
- 380.22
- MOL File
- 1239513-63-3.mol
Poloxipan Property
- Boiling point:
- 500.9±60.0 °C(Predicted)
- Density
- 1.73±0.1 g/cm3(Predicted)
- pka
- -2.84±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- API0014077
- Product name
- POLOXIPAN
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $682
- Updated
- 2021/12/16
- Product number
- API0014077
- Product name
- POLOXIPAN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $791.18
- Updated
- 2021/12/16
Poloxipan Chemical Properties,Usage,Production
Description
Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc.
Uses
Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research[1].
References
[1] Kumar S, et al. PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis. Biomed Res Int. 2015;2015:705745. DOI:10.1155/2015/705745
Poloxipan Preparation Products And Raw materials
Raw materials
Preparation Products
Poloxipan Suppliers
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 29573
- Advantage
- 58