ChemicalBook > CAS DataBase List > RO 9187

RO 9187

Product Name
RO 9187
CAS No.
876708-03-1
Chemical Name
RO 9187
Synonyms
RO 9187;RO 9187;RO9187;2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-;4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2 (1H )-pyrimidinone;4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
CBNumber
CB62628361
Molecular Formula
C9H12N6O5
Formula Weight
284.22878
MOL File
876708-03-1.mol
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RO 9187 Property

Melting point:
188.0-189.0℃
storage temp. 
Store at -20°C
solubility 
H2O : 7.14 mg/mL (25.12 mM; Need ultrasonic)
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0954
Product name
RO-9187
Purity
≥98.0%
Packaging
5mg
Price
$244
Updated
2021/12/16
ChemScene
Product number
CS-0954
Product name
RO-9187
Purity
≥98.0%
Packaging
10mg
Price
$319
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611734
Product name
RO-9187
Packaging
10mg
Price
$440.3
Updated
2021/12/16
ChemScene
Product number
CS-0954
Product name
RO-9187
Purity
≥98.0%
Packaging
50mg
Price
$869
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611734
Product name
RO-9187
Packaging
50mg
Price
$882.3
Updated
2021/12/16
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RO 9187 Chemical Properties,Usage,Production

Biological Activity

RO-9187 is a potent inhibitor of HCV viral replication with IC50 value of 171 nM.

in vitro

RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. It inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.

in vivo

Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.

target

IC50: 171 nM (HCV)

RO 9187 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 9187 Suppliers

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876708-03-1, RO 9187Related Search:

2'-Deoxycytidine gamma-Cyclodextrin

  • RO 9187
  • 4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
  • RO 9187;RO9187
  • 4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2 (1H )-pyrimidinone
  • 2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-
  • 876708-03-1