ST101

Product Name: ST101
CAS No.: 887603-94-3
Chemical Name: ST101
Synonyms: ST101;ZSET 1446;ST 101(ZSET1446);ZSET1446, 10 mM in DMSO;ST101;ZSET-1446;ZSET 1446;ST-101;ST 101;1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE;1',3'-Dihydro-2H-spiro[imidazo[1,2-a]pyridine-3,2'-inden]-2-one;Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro-;ST101,Inhibitor,ST 101,Calcium Channel,Nicotinic acetylcholine receptors,Ca2+ channels,ZSET 1446,ZSET1446,inhibit,nAChR,Ca channels
CBNumber: CB62628543
Molecular Formula: C15H12N2O
Formula Weight: 236.27
MOL File: 887603-94-3.mol

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ST101 Property

Boiling point:: 403.4±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 34 mg/mL (143.90 mM)
form: Solid
pka: 3.13±0.20(Predicted)
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6039
Product name: ZSET1446
Purity: 98.13%
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-6039
Product name: ZSET1446
Purity: 98.13%
Packaging: 5mg
Price: $225
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014203
Product name: ZSET-1446
Purity: 95.00%
Packaging: 5MG
Price: $501.44
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611424
Product name: ZSET1446
Packaging: 5mg
Price: $538.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611424
Product name: ZSET1446
Packaging: 10mg
Price: $555.9
Updated: 2021/12/16

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ST101 Chemical Properties,Usage,Production

Uses

ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.

in vivo

ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone^[2]. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Further, 8-week treatment of ZSET1446 significantly reduces the total number of Aβ-positive granules in the hippocampus^[3].

References

[1] Takeda K, et al. Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus. J Pharmacol Exp Ther. 2016 Feb;356(2):445-55 DOI:10.1124/jpet.115.229021
[2] Yamaguchi Y, et al. Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus. J Pharmacol Sci. 2013;123(4):347-55. Epub 2013 Nov 29. DOI:10.1254/jphs.13042fp
[3] Yamaguchi Y, et al. Effects of ZSET1446/ST101 on cognitive deficits and amyloid β deposition in the senescence accelerated prone mouse brain. J Pharmacol Sci. 2012;119(2):160-6. DOI:10.1254/jphs.12036fp

ST101 Preparation Products And Raw materials

Raw materials

Preparation Products

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ST101 Suppliers

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887603-94-3, ST101Related Search:

ST101

ZSET 1446

ST 101(ZSET1446)

1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN]-2-ONE

ST101;ZSET-1446;ZSET 1446;ST-101;ST 101

Spiro[imidazo[1,2-a]pyridine-3(2H),2'-[2H]inden]-2-one, 1',3'-dihydro-

ST101,Inhibitor,ST 101,Calcium Channel,Nicotinic acetylcholine receptors,Ca2+ channels,ZSET 1446,ZSET1446,inhibit,nAChR,Ca channels

1',3'-Dihydro-2H-spiro[imidazo[1,2-a]pyridine-3,2'-inden]-2-one

ZSET1446, 10 mM in DMSO

887603-94-3