6-Hydroxy-2-quinolinecarboxylic acid
- Product Name
- 6-Hydroxy-2-quinolinecarboxylic acid
- CAS No.
- 75434-18-3
- Chemical Name
- 6-Hydroxy-2-quinolinecarboxylic acid
- Synonyms
- 6-hydroxyquinoline-2-carboxylic acid;6-Hydroxy-2-quinolinecarboxylic acid;2-Quinolinecarboxylic acid, 6-hydroxy-
- CBNumber
- CB62629944
- Molecular Formula
- C10H7NO3
- Formula Weight
- 189.17
- MOL File
- 75434-18-3.mol
6-Hydroxy-2-quinolinecarboxylic acid Property
- Melting point:
- 242-245o C
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- color
- Pale Yellow to Pale Green
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H955650
- Product name
- 6-hydroxyquinoline-2-carboxylicacid
- Packaging
- 50mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- H955650
- Product name
- 6-hydroxyquinoline-2-carboxylicacid
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 4990AQ
- Product name
- 6-hydroxyquinoline-2-carboxylicacid
- Packaging
- 100mg
- Price
- $309.2
- Updated
- 2021/12/16
- Product number
- CD11062117
- Product name
- 6-Hydroxyquinoline-2-carboxylicacid
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- 75434183
- Product name
- 6-Hydroxyquinoline-2-carboxylicacid
- Packaging
- 100mg
- Price
- $343.7
- Updated
- 2021/12/16
6-Hydroxy-2-quinolinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
75433-99-7
75434-18-3
6-Methoxyquinoline-2-carboxylic acid (4 g, 0.019 mol) was used as starting material and suspended in 48% aqueous hydrobromic acid (80 ml). The reaction mixture was heated to reflux at 125°C overnight. Upon completion of the reaction, the mixture was cooled to 0 °C and the pH was adjusted to 6-7 by slow addition of aqueous ammonium hydroxide. subsequently, dilute hydrochloric acid was added dropwise until the pH reached 3-4, at which point the target product, 6-hydroxy-2-quinolinecarboxylic acid, precipitated as a solid. The precipitate was collected by filtration, washed thoroughly with deionized water, and finally dried in a vacuum drying oven to give 3.5 g of the product in the form of a yellow solid (0.0185 mol, 97% yield). The molecular weight of the product was confirmed to be 190.1 (M+H)+ by mass spectrometry.
References
[1] Patent: US2006/84679, 2006, A1. Location in patent: Page/Page column 12
[2] Patent: US4461896, 1984, A
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 15, p. 4495 - 4500
6-Hydroxy-2-quinolinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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