Takeda-6d

Product Name: Takeda-6d
CAS No.: 1125632-93-0
Chemical Name: Takeda-6d
Synonyms: CS-2670;Takeda-6d;TAKEDA 6D;TAKEDA6D;Benzamide, 2-chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)amino]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]-;2-Chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)aMino][1,3]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]benzaMide;antitumor,HUVEC cells,VEGFR,inhibit,antiangiogenesis,Raf,Vascular endothelial growth factor receptor,PKR-like endoplasmic reticulum kinase,orally active,Takeda-6D,Inhibitor,Takeda 6d,PERK,Takeda6d,Raf kinases,Protein kinase R-like endoplasmic reticulum kinase
CBNumber: CB62642552
Molecular Formula: C27H19ClFN5O3S
Formula Weight: 547.99
MOL File: 1125632-93-0.mol

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Takeda-6d Property

storage temp.: -20°C
solubility: DMSO: 20mM
form: A solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: SYN-1168-M001
Product name: Takeda-6d
Purity: ≥95%
Packaging: 1mg
Price: $211
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002082
Product name: TAKEDA-6D
Purity: 95.00%
Packaging: 5MG
Price: $498.94
Updated: 2021/12/16

DC Chemicals

Product number: DC10065
Product name: Takeda-6d
Purity: >98%
Packaging: 25mg
Price: $600
Updated: 2021/12/16

DC Chemicals

Product number: DC10065
Product name: Takeda-6d
Purity: >98%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

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Takeda-6d Chemical Properties,Usage,Production

Biological Activity

Takeda-6d is a dual inhibitor of RAF kinases and VEGFR2.1 It inhibits wild-type B-RAF, mutant B-RAFV600E, and C-RAF (IC50s = 12, 7, and 1.5 nM, respectively), as well as VEGFR2 (IC50 = 2.8 nM). Takeda-6d is selective for these kinases over a panel of 19 additional kinases (IC50s = >1,000 nM) but does inhibit FGFR3, PDGFRα, and PDGFRβ (IC50s = 22, 12, and 5.5 nM, respectively). It inhibits MEK and ERK1/2 phosphorylation in several colon cancer and melanoma cell lines expressing B-RAFV600E when used at concentrations ranging from 100 to 1,600 nM, as well as inhibits VEGF-A-induced phosphorylation of VEGFR2 in VEGFR2-overexpressing KDR cells (IC50 = 0.53 nM). Takeda-6d (10 mg/kg) reduces tumor volume in an A375 melanoma mouse xenograft model.

References

1.Okaniwa, M., Hirose, M., Imada, T., et al.Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffoldsJ. Med. Chem.55(7)3452-3478(2012)

Takeda-6d Preparation Products And Raw materials

Raw materials

Preparation Products

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Takeda-6d Suppliers

China 29 United Kingdom 1 United States 4 Global 34

SYN|thesis med chem P/L

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1125632-93-0, Takeda-6dRelated Search:

Takeda103A

Takeda-6d

2-Chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)aMino][1,3]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]benzaMide

TAKEDA 6D;TAKEDA6D

CS-2670

Benzamide, 2-chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)amino]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]-

antitumor,HUVEC cells,VEGFR,inhibit,antiangiogenesis,Raf,Vascular endothelial growth factor receptor,PKR-like endoplasmic reticulum kinase,orally active,Takeda-6D,Inhibitor,Takeda 6d,PERK,Takeda6d,Raf kinases,Protein kinase R-like endoplasmic reticulum kinase

1125632-93-0

C27H19ClFN5O3S