2-(4-(adaMantan-1-yl)phenoxy)acetic acid
- Product Name
- 2-(4-(adaMantan-1-yl)phenoxy)acetic acid
- CAS No.
- 52804-26-9
- Chemical Name
- 2-(4-(adaMantan-1-yl)phenoxy)acetic acid
- Synonyms
- ST071038;BAS 00285042;Oprea1_723072;Oprea1_157400;CBDivE_002637;[4-(Adamantyl-1)phenoxy]acetic acid;(4-AdaMantan-1-yl-phenoxy)-aceticacid;2-[4-(1-adamantyl)phenoxy]acetic acid;2-[4-(1-adamantyl)phenoxy]ethanoic acid;[4-(1-adamantyl)phenoxy]acetic acid,95%
- CBNumber
- CB62642572
- Molecular Formula
- C18H22O3
- Formula Weight
- 286.37
- MOL File
- 52804-26-9.mol
2-(4-(adaMantan-1-yl)phenoxy)acetic acid Property
- Melting point:
- 168-170℃ (acetic acid water )
- Boiling point:
- 441.1±28.0 °C(Predicted)
- Density
- 1.226±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.21±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0063192
- Product name
- 2-(4-(Adamantan-1-yl)phenoxy)aceticacid
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- CS-0063192
- Product name
- 2-(4-(Adamantan-1-yl)phenoxy)aceticacid
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- FA131202
- Product name
- [4-(1-Adamantyl)phenoxy]acetic acid
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FA131202
- Product name
- [4-(1-Adamantyl)phenoxy]acetic acid
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0063192
- Product name
- 2-(4-(Adamantan-1-yl)phenoxy)aceticacid
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
2-(4-(adaMantan-1-yl)phenoxy)acetic acid Chemical Properties,Usage,Production
Synthesis
52804-25-8
52804-26-9
LiOH-H2O (0.29 g, 7.00 mmol) was added to a solution of 2-(4-(1-adamantyl)phenoxy)ethyl acetate (1.10 g, 3.50 mmol) in THF/H2O (1:1, 20.0 mL). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, it was acidified with 10% HCl solution to pH 2. The organic layer was separated by adding EtOAc for extraction. After concentration of the organic phase, the residue was purified by silica gel column chromatography (eluent: CH2Cl2/MeOH = 30:1) to afford 2-(4-(1-adamantyl)phenoxy)acetic acid as a white solid (0.61 g, 61.3% yield).1H NMR (CDCl3, 500 MHz) δ 7.29 (d, 2H, J = 6.75 Hz, Ar-H), 6.87 (d, 2H, Ar-H), 6.87 (d, 2H, J = 6.75 Hz, Ar-H), 7.29 (d, 2H, J = 6.75 Hz, Ar-H). 6.87 (d, 2H, J = 6.74 Hz, Ar-H), 4.61 (s, 2H, -OCH2COO-), 2.04 (s, 4H, adamantyl), 1.86 (m, 6H, adamantyl), 1.76 (m, 6H, adamantyl); 13C NMR (CDCl3, 125 MHz) δ 156.16, 142.71, 127.35, 114.31, 64.21, 42.51, 36.84, 36.17, 28.16; LCMS m/z calculated value (MH+) 287.16, measured value 287.26.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6305 - 6310
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 7, p. 1675 - 1684
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 24, p. 7456 - 7460
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1453 - 1456
[5] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 12, p. 3826 - 3829
2-(4-(adaMantan-1-yl)phenoxy)acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-(adaMantan-1-yl)phenoxy)acetic acid manufacturers
- Product
- 2-(4-(adaMantan-1-yl)phenoxy)acetic acid 52804-26-9
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-21