SIRT2 Inhibitor, Inactive Control, AGK7

Product Name: SIRT2 Inhibitor, Inactive Control, AGK7
CAS No.: 304896-21-7
Chemical Name: SIRT2 Inhibitor, Inactive Control, AGK7
Synonyms: AGK7;AGK7, structural isomer of AGK2;SIRT2 Inhibitor, Inactive Control;SIRT2 Inhibitor, Inactive Control, AGK7;2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide;2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-;Parkinson's disease,sirtuin 2,morphology,SIRT2 Inhibitor,Inactive Control,AGK 7,Drosophila,inhibit,toxicity,Inhibitor,AGK7,alpha-synuclein,dopaminergic cell death,AGK-7,Sirtuin
CBNumber: CB62645098
Molecular Formula: C23H13Cl2N3O2
Formula Weight: 434.27
MOL File: 304896-21-7.mol

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SIRT2 Inhibitor, Inactive Control, AGK7 Property

storage temp.: +2C to +8C
solubility: ≤0.5mg/ml in DMSO;0.2mg/ml in dimethyl formamide
form: Yellow solid
color: yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 566326
Product name: SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem
Packaging: 5mg
Price: $238
Updated: 2023/01/07

Cayman Chemical

Product number: 16152
Product name: AGK7
Purity: ≥95%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 16152
Product name: AGK7
Purity: ≥95%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 16152
Product name: AGK7
Purity: ≥95%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 16152
Product name: AGK7
Purity: ≥95%
Packaging: 25mg
Price: $437
Updated: 2024/03/01

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SIRT2 Inhibitor, Inactive Control, AGK7 Chemical Properties,Usage,Production

Description

AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC₅₀ = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group. AGK7 has IC₅₀ values greater than 50 μM on SIRT1 and SIRT2 and greater than 5 μM on SIRT3.

Uses

AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1].

References

[1]. outeiro tf, kontopoulos e, altmann sm, et al. sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of parkinson's disease. science. 2007 jul 27;317(5837):516-9.
[2]. cole pa. chemical probes for histone-modifying enzymes. nat chem biol. 2008 oct;4(10):590-7.

SIRT2 Inhibitor, Inactive Control, AGK7 Preparation Products And Raw materials

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SIRT2 Inhibitor, Inactive Control, AGK7 Suppliers

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304896-21-7, SIRT2 Inhibitor, Inactive Control, AGK7Related Search:

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304896-21-7