EVP-6124 (hydrochloride)
- Product Name
- EVP-6124 (hydrochloride)
- CAS No.
- 550999-74-1
- Chemical Name
- EVP-6124 (hydrochloride)
- Synonyms
- MT4666);EVP-6124 Hcl;EVP6124;EVP 6124;Encenicline, HCl salt;EVP-6124 (hydrochloride);Encenicline hydrochloride;Encenicline HCl salt (EVP6124;Encenicline hydrochloride (EVP-6124);Encenicline (EVP-6124) hydrochloride;Encenicline hydrochloride, 10 mM in DMSO
- CBNumber
- CB62645139
- Molecular Formula
- C16H18Cl2N2OS
- Formula Weight
- 357.29792
- MOL File
- 550999-74-1.mol
EVP-6124 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥100.4 mg/mL in EtOH with gentle warming; ≥17.87 mg/mL in DMSO
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E1453
- Product name
- EVP-6124 Hydrochloride
- Packaging
- 10MG
- Price
- $168
- Updated
- 2025/07/31
- Product number
- 30073
- Product name
- EVP-6124 (hydrochloride)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 30073
- Product name
- EVP-6124 (hydrochloride)
- Packaging
- 50mg
- Price
- $929
- Updated
- 2024/03/01
- Product number
- 30073
- Product name
- EVP-6124 (hydrochloride)
- Packaging
- 10mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 30073
- Product name
- EVP-6124 (hydrochloride)
- Packaging
- 25mg
- Price
- $493
- Updated
- 2024/03/01
EVP-6124 (hydrochloride) Chemical Properties,Usage,Production
Uses
Encenicline hydrochloride is a selective partial agonist of the a7 nicotinic acetylcholine receptor being developed for the cognitive impairment in Alzheimer’s disease and schizophrenia.
in vivo
Encenicline hydrochloride has good brain penetration and an adequate exposure time. Encenicline hydrochloride (0.3 mg/kg, p.o.) significantly restores memory function in scopolamine-treated rats (0.1 mg/kg, i.p.) in an object recognition task (ORT). Although donepezil at 0.1 mg/kg, p.o. or Encenicline hydrochloride at 0.03 mg/kg, p.o. did not improve memory in this task, co-administration of these sub-efficacious doses fully restored memory. In a natural forgetting test, an ORT with a 24 h retention time, Encenicline hydrochloride improved memory at 0.3 mg/kg, p.o. This improvement is blocked by the selective α7 nAChR antagonist methyllycaconitine (0.3 mg/kg, i.p. or 10 μg, i.c.v.). Encenicline hydrochloride is found to bind moderately to rat plasma proteins with a mean fu of 0.11±0.01 (mean±SD) or 11%. Over a range of 0.1-30 mg/kg, p.o., Encenicline hydrochloride demonstrates proportional dose escalation. Tmax is at 4 h in plasma and 2 h brain, although the brain concentrations remained similar between 2 and 8 h. The B:P ratios are 1.7-5.1 between 1 and 8 h[1]. Pharmacokinetic studies have shown that Encenicline hydrochloride (0.4 mg/kg, i.p.) reaches peak brain concentration 2 hr after administration and remains at effective concentrations for at least 4 hr. Encenicline hydrochloride is administered to WT mice at ZT0 (0.4 mg/kg i.p single dose) and significantly increases the saturation index of NMDARs in slices obtained 4 hr later without causing prolonged wakefulness or enhanced locomotor activity [2].
EVP-6124 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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