ChemicalBook > CAS DataBase List > Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)

Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)

Product Name: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
CAS No.: 118591-58-5
Chemical Name: Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
Synonyms: peg2-tos;Tos-PEG2-OH;OH-PEG2-Tos;HO-PEG2-OTS;CAS_118591-58-5;Tos-PEG2-alcohol;Diethylene glycol p-toluenesulfonate;diethylene glycol mono-p-toluenesulfonate;2-(2-Hydroxyethoxy)ethyl 4-Methylbenzensulfonate;2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
CBNumber: CB62648165
Molecular Formula: C11H16O5S
Formula Weight: 260.30674
MOL File: 118591-58-5.mol

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Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Property

Boiling point:: 427.4±30.0 °C(Predicted)
Density: 1.256±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.32±0.10(Predicted)
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C11H16O5S/c1-10-2-4-11(5-3-10)17(13,14)16-9-8-15-7-6-12/h2-5,12H,6-9H2,1H3
InChIKey: KLDLLRZCWYKJBD-UHFFFAOYSA-N
SMILES: C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00334
Product name: 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
Packaging: 1G
Price: $497
Updated: 2025/07/31

Matrix Scientific

Product number: 182262
Product name: 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
Purity: 95%
Packaging: 5g
Price: $1238
Updated: 2021/12/16

Chemenu

Product number: CM248031
Product name: 2-(2-Hydroxyethoxy)ethyl4-methylbenzenesulfonate
Purity: 95+%
Packaging: 1g
Price: $622
Updated: 2021/12/16

Alichem

Product number: 118591585
Product name: 2-(2-Hydroxyethoxy)ethyl4-methylbenzenesulfonate
Packaging: 1g
Price: $671.65
Updated: 2021/12/16

A1 Biochem Labs

Product number: 6571312
Product name: 2-(2-Hydroxyethoxy)ethyl4-methylbenzenesulfonate
Purity: 95%
Packaging: 5G
Price: $750
Updated: 2021/12/16

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Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Chemical Properties,Usage,Production

Uses

Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Synthesis

98-59-9

111-46-6

118591-58-5

The general procedure for the synthesis of 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate from p-toluenesulfonyl chloride and diethylene glycol was as follows: first, the diethylene glycol was protected with a monohydroxy group. This was done as follows: in a dichloromethane solvent, potassium iodide (0.2 eq.) was added as a catalyst, followed by freshly prepared silver oxide (1.5 eq.) and p-toluenesulfonyl chloride (1.1 eq.). The reaction mixture was stirred at room temperature for 8-10 h. Upon completion of the reaction, mono-p-toluenesulfonyl-protected diethylene glycol was obtained in 97-99% yield. This step provides a selectively protected intermediate for the subsequent reaction with aconitic acid.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: OH-PEG2-Tos 118591-58-5
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-25

118591-58-5, Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)Related Search:

Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)

2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate

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diethylene glycol mono-p-toluenesulfonate

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4Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)

2-(2-Hydroxyethoxy)ethyl 4-Methylbenzensulfonate

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Tos-PEG2-OH/Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-methylbenzenesulfonate)

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118591-58-5

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C11H16O5S