4-BroMo-1-(iso-propyl)-1H-iMidazole
- Product Name
- 4-BroMo-1-(iso-propyl)-1H-iMidazole
- CAS No.
- 623577-60-6
- Chemical Name
- 4-BroMo-1-(iso-propyl)-1H-iMidazole
- Synonyms
- 4-Bromo-1-isopropyl-imidazole;4-bromo-1-propan-2-ylimidazole;4-Bromo-1-(prop-2-yl)-1H-imidazole;4-BroMo-1-(iso-propyl)-1H-iMidazole;1H-Imidazole, 4-bromo-1-(1-methylethyl)-
- CBNumber
- CB62648190
- Molecular Formula
- C6H9BrN2
- Formula Weight
- 189.05
- MOL File
- 623577-60-6.mol
4-BroMo-1-(iso-propyl)-1H-iMidazole Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid-Liquid Mixture
Safety
- HS Code
- 29332900
N-Bromosuccinimide Price
- Product number
- B567263
- Product name
- 4-bromo-1-isopropyl-1H-imidazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 101675
- Product name
- 4-Bromo-1-(iso-propyl)-1H-imidazole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $208
- Updated
- 2021/12/16
- Product number
- 6885AE
- Product name
- 4-Bromo-1-(iso-propyl)-1H-imidazole
- Packaging
- 500mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- 101675
- Product name
- 4-Bromo-1-(iso-propyl)-1H-imidazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $536
- Updated
- 2021/12/16
- Product number
- 3H32-9-5G
- Product name
- 4-Bromo-1-isopropyl-1H-imidazole
- Packaging
- 1g
- Price
- $600
- Updated
- 2021/12/16
4-BroMo-1-(iso-propyl)-1H-iMidazole Chemical Properties,Usage,Production
Synthesis
75-26-3
623577-60-6
General procedure for the synthesis of 4-bromo-1-isopropyl-1H-imidazole from 2-bromopropane: 4-bromo-1H-imidazole (1.0 g, 6.80 mmol) was dissolved in dimethylformamide (5 mL) at 0 °C and sodium hydride (60% oil suspension, 326 mg, 8.20 mmol) was added with stirring. The reaction mixture was gradually warmed to room temperature and stirred continuously for 30 min. Subsequently, 2-bromopropane (0.70 mL, 7.48 mmol) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 15 hours under nitrogen protection. Upon completion of the reaction, the reaction was quenched with water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, washed with water (20 mL) and extracted with 1 M hydrochloric acid (3 x 20 mL). The acidic aqueous phases were combined, washed with ethyl acetate (20 mL) and the pH was adjusted to 12 with ammonium hydroxide, followed by extraction with ethyl acetate (3 × 20 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The target product, 4-bromo-1-isopropyl-1H-imidazole, was obtained as a light brown oil (380 mg, 30% yield) by preparative HPLC using an ethyl acetate-isohexane gradient elution.1H NMR (400 MHz, CDCl3) δ: 1.47 (6H, d, J = 6.8 Hz), 4.28-4.32 (1H, m), 6.92 ( 1H, d, J = 1.5 Hz), 7.40 (1H, d, J = 1.5 Hz).MS (ES+) m/z: 189, 191 ([MH]+).
References
[1] Patent: WO2003/93252, 2003, A1. Location in patent: Page/Page column 117
4-BroMo-1-(iso-propyl)-1H-iMidazole Preparation Products And Raw materials
Raw materials
Preparation Products
4-BroMo-1-(iso-propyl)-1H-iMidazole Suppliers
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 020-82185713,82185709 13418171485
- Fax
- 020-82185696
- sales@chem-stone.com
- Country
- China
- ProdList
- 744
- Advantage
- 56
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-11111111 11111111111
- Fax
- qq:546919421
- 546919421@qq.com
- Country
- China
- ProdList
- 3518
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 15861130028; 15861130028
- 956912955@qq.com
- Country
- China
- ProdList
- 296
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 021-65232103 17602124823
- combiphos@vip.qq.com
- Country
- China
- ProdList
- 30000
- Advantage
- 58