L778123
- Product Name
- L778123
- CAS No.
- 253863-00-2
- Chemical Name
- L778123
- Synonyms
- L-778123HCl;L-778123 (hydrochloride);L-778123;L 778123;L778123;L-778123 hydrochloride, 10 mM in DMSO;L-778123 hydrochloride (L-778,123 hydrochloride);L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 HCL; L-778123 HYDROCHLORIDE;4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride;4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride;4-((5-((4-(3-Chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride;4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile monohydrochloride
- CBNumber
- CB62648741
- Molecular Formula
- C22H21Cl2N5O
- Formula Weight
- 442.34104
- MOL File
- 253863-00-2.mol
L778123 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 12.5 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22940
- Product name
- L-778,123
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 22940
- Product name
- L-778,123
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $165
- Updated
- 2024/03/01
- Product number
- 22940
- Product name
- L-778,123
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $385
- Updated
- 2024/03/01
- Product number
- 22940
- Product name
- L-778,123
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $672
- Updated
- 2024/03/01
- Product number
- orb573082
- Product name
- L-778123 HCl
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
L778123 Chemical Properties,Usage,Production
Uses
L-778123 hydrochloride is a dual inhibitor of FPTase and GGPTase-I, with IC50 values of 2 nM and 98 nM respectively.
Definition
ChEBI: L-778,123 hydrochloride is the hydrochloride salt of L-778,123. It is a dual inhibitor of FPTase and GGPTase-I (IC50 of 2nM and 98nm, respectively) and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor, an EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor and a radiosensitizing agent. It contains a L-778,123 (free base).
in vivo
L-778123 (50 mg/kg/day, infusion, 7 days) hydrochloride inhibits both HDJ2 and Rap1A prenylation in PBMCs of dogs, but without inhibition in Ki-Ras prenylation[1].
References
[1] Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. PMID:12479371
[2] Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77. DOI:10.5681/apb.2013.012
[3] Fredrick O. Onono, et al. The Farnesyltransferase Inhibitor (FTI) L-778,123 Displays Promising Anti-Leukemia Activity. Blood (2008); 112 (11): 2627.
[4] Si MS, et al. Inhibition of lymphocyte activation and function by the prenylation inhibitor L-778,123. Invest New Drugs. 2005 Jan;23(1):21-9. DOI:10.1023/B:DRUG.0000047102.26698.08
L778123 Preparation Products And Raw materials
Raw materials
Preparation Products
L778123 Suppliers
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View Lastest Price from L778123 manufacturers
- Product
- 4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride 253863-00-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01