BTZ043 (BTZ038, BTZ044)

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BTZ043 (BTZ038, BTZ044)

Product Name: BTZ043 (BTZ038, BTZ044)
CAS No.: 957217-65-1
Chemical Name: BTZ043 (BTZ038, BTZ044)
Synonyms: BTZ038;BTZ044;BTZ 10526038;BTZ038; BTZ044;BTZ043 (BTZ038, BTZ044);Benzothiazinone 10526038;2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-;2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one;2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one BTZ043 Racemate
CBNumber: CB62650632
Molecular Formula: C17H16F3N3O5S
Formula Weight: 431.39
MOL File: 957217-65-1.mol

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BTZ043 (BTZ038, BTZ044) Property

Boiling point:: 547.6±60.0 °C(Predicted)
Density: 1.68±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥10.4 mg/mL in DMSO with gentle warming; ≥3.27 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: -0.51±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0019700
Product name: BTZ043(Racemate)
Purity: 98.77%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0019700
Product name: BTZ043(Racemate)
Purity: 98.77%
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ApexBio Technology

Product number: A5118
Product name: BTZ043Racemate
Packaging: 5mg
Price: $126
Updated: 2021/12/16

ApexBio Technology

Product number: A5118
Product name: BTZ043Racemate
Packaging: 10mg
Price: $242
Updated: 2021/12/16

ChemScene

Product number: CS-0019700
Product name: BTZ043(Racemate)
Purity: 98.77%
Packaging: 50mg
Price: $440
Updated: 2021/12/16

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BTZ043 (BTZ038, BTZ044) Chemical Properties,Usage,Production

Biological Activity

mic: 1 ng/ml (2.3 nm) for m. tuberculosis h37rv and 4 ng/ml (9.2 nm) for mycobacterium smegmatisthe loss of human lives to tuberculosis (tb) continues unabated as a result of poverty, synergy with the hiv/aids pandemic, and the emergence of multidrug- and extensively drug-resistant strains of mycobacterium tuberculosis. btz043 is the most advanced candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant tb.

in vitro

btz043 displayed similar activity against all clinical isolates of m. tuberculosis that were tested, including extensively drug-resistant and multidrug-resistant strains, indicating that it targets a previously unknown biological function. btz043 is bactericidal, reducing viability in vitro by more than 1000-fold in under 72 hours, which is comparable to the inh killing effect [1].

in vivo

the in vivo efficacy of btz043 was assessed 4 weeks after a low-dose aerosol infection of in the chronic balb/c mice model of tb. four weeks of treatment with btz043 reduced the bacterial load in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. additional findings suggest that btz efficacy is time- rather than dose-dependent [1].

target

Target	Value
DprE1

References

[1] makarov v, manina g, mikusova k, et al. benzothiazinones kill mycobacterium tuberculosis by blocking arabinan synthesis. science. 2009 may 8;324(5928):801-4.

BTZ043 (BTZ038, BTZ044) Preparation Products And Raw materials

Raw materials

Preparation Products

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957217-65-1, BTZ043 (BTZ038, BTZ044)Related Search:

PHA-848125 AZD 5438 MLN8054

BTZ043 (BTZ038, BTZ044)

4H-1,3-Benzothiazin-4-one, 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-

2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one

2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one BTZ043 Racemate

Benzothiazinone 10526038

BTZ 10526038

2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one

BTZ038

BTZ038; BTZ044

BTZ044

957217-65-1

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