ChemicalBook > CAS DataBase List > BTZ043 (BTZ038, BTZ044)
BTZ043 (BTZ038, BTZ044)
- Product Name
- BTZ043 (BTZ038, BTZ044)
- CAS No.
- 957217-65-1
- Chemical Name
- BTZ043 (BTZ038, BTZ044)
- Synonyms
- BTZ038;BTZ044;BTZ 10526038;BTZ038; BTZ044;BTZ043 (BTZ038, BTZ044);Benzothiazinone 10526038;2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-;2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one;2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one BTZ043 Racemate
- CBNumber
- CB62650632
- Molecular Formula
- C17H16F3N3O5S
- Formula Weight
- 431.39
- MOL File
- 957217-65-1.mol
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BTZ043 (BTZ038, BTZ044) Property
- Boiling point:
- 547.6±60.0 °C(Predicted)
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥10.4 mg/mL in DMSO with gentle warming; ≥3.27 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- -0.51±0.20(Predicted)
- color
- White to light yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0019700
- Product name
- BTZ043(Racemate)
- Purity
- 98.77%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0019700
- Product name
- BTZ043(Racemate)
- Purity
- 98.77%
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A5118
- Product name
- BTZ043Racemate
- Packaging
- 5mg
- Price
- $126
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A5118
- Product name
- BTZ043Racemate
- Packaging
- 10mg
- Price
- $242
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0019700
- Product name
- BTZ043(Racemate)
- Purity
- 98.77%
- Packaging
- 50mg
- Price
- $440
- Updated
- 2021/12/16
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BTZ043 (BTZ038, BTZ044) Chemical Properties,Usage,Production
Biological Activity
mic: 1 ng/ml (2.3 nm) for m. tuberculosis h37rv and 4 ng/ml (9.2 nm) for mycobacterium smegmatisthe loss of human lives to tuberculosis (tb) continues unabated as a result of poverty, synergy with the hiv/aids pandemic, and the emergence of multidrug- and extensively drug-resistant strains of mycobacterium tuberculosis. btz043 is the most advanced candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant tb.
in vitro
btz043 displayed similar activity against all clinical isolates of m. tuberculosis that were tested, including extensively drug-resistant and multidrug-resistant strains, indicating that it targets a previously unknown biological function. btz043 is bactericidal, reducing viability in vitro by more than 1000-fold in under 72 hours, which is comparable to the inh killing effect [1].
in vivo
the in vivo efficacy of btz043 was assessed 4 weeks after a low-dose aerosol infection of in the chronic balb/c mice model of tb. four weeks of treatment with btz043 reduced the bacterial load in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. additional findings suggest that btz efficacy is time- rather than dose-dependent [1].
target
| Target | Value |
| DprE1 |
References
[1] makarov v, manina g, mikusova k, et al. benzothiazinones kill mycobacterium tuberculosis by blocking arabinan synthesis. science. 2009 may 8;324(5928):801-4.
BTZ043 (BTZ038, BTZ044) Preparation Products And Raw materials
Raw materials
Preparation Products
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