Streptochlorin

Product Name: Streptochlorin
CAS No.: 120191-51-7
Chemical Name: Streptochlorin
Synonyms: SF 2583A;Streptochlorin;Antibiotic SF 2583A;3-(4-Chloro-5-oxazolyl)-1H-indole;4-Chloro-5-(1H-indol-3-yl)oxazole;1H-Indole, 3-(4-chloro-5-oxazolyl)-;Streptochlorin, Antiangiogenic agent
CBNumber: CB62650834
Molecular Formula: C11H7ClN2O
Formula Weight: 218.63908
MOL File: 120191-51-7.mol

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Streptochlorin Property

storage temp.: Store at -20°C
solubility: DMSO: soluble; Methanol: soluble
form: A solid
color: Crystalline

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27605
Product name: Streptochlorin
Packaging: 1mg
Price: $225
Updated: 2024/03/01

Cayman Chemical

Product number: 27605
Product name: Streptochlorin
Packaging: 5mg
Price: $844
Updated: 2024/03/01

Usbiological

Product number: 207409
Product name: Streptochlorin
Packaging: 250ug
Price: $316
Updated: 2021/12/16

AK Scientific

Product number: 3685DF
Product name: Streptochlorin
Packaging: 1mg
Price: $417
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009883
Product name: STREPTOCHLORIN
Purity: 95.00%
Packaging: 5MG
Price: $456.05
Updated: 2021/12/16

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Streptochlorin Chemical Properties,Usage,Production

Description

Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).

Uses

Streptochlorin is an antineoplastic agent and a potential chemotherapeutic agent for treating cholangiocarcinoma.

storage

+4°C

Streptochlorin Preparation Products And Raw materials

Raw materials

Preparation Products

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Streptochlorin Suppliers

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120191-51-7, StreptochlorinRelated Search:

Streptochlorin

3-(4-Chloro-5-oxazolyl)-1H-indole

Antibiotic SF 2583A

SF 2583A

1H-Indole, 3-(4-chloro-5-oxazolyl)-

4-Chloro-5-(1H-indol-3-yl)oxazole

Streptochlorin, Antiangiogenic agent

120191-51-7