ChemicalBook > CAS DataBase List > S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

Product Name
S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride
CAS No.
86867-01-8
Chemical Name
S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride
Synonyms
S-(5′SAM; ADOMET;-Adenosyl)-LL-methionine chloride dihydrochloride
CBNumber
CB62655576
Molecular Formula
C15H24Cl2N6O5S
Formula Weight
471.35
MOL File
86867-01-8.mol
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S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Property

storage temp. 
-20°C
solubility 
H2O: soluble100mg/mL
form 
A lyophilized powder
color 
Off-white to light yellow
BRN 
6560002
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-68/20/21/22
Safety Statements 
36-45
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7007
Product name
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
Purity
≥75%
Packaging
5mg
Price
$70.3
Updated
2024/03/01
Sigma-Aldrich
Product number
A7007
Product name
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
Purity
≥75%
Packaging
1g
Price
$1350
Updated
2024/03/01
Cayman Chemical
Product number
13956
Product name
S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
13956
Product name
S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
Purity
≥95%
Packaging
2.5mg
Price
$90
Updated
2024/03/01
Sigma-Aldrich
Product number
A7007
Product name
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
Purity
≥75%
Packaging
25mg
Price
$91.8
Updated
2024/03/01
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S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Chemical Properties,Usage,Production

Description

S-(5''-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine . SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine. Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.

Uses

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.

General Description

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Suppliers

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