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3-Bromo-4-fluorobenzeneacetonitrile

Product Name
3-Bromo-4-fluorobenzeneacetonitrile
CAS No.
501420-63-9
Chemical Name
3-Bromo-4-fluorobenzeneacetonitrile
Synonyms
2-(3-Bromo-4-fluorophenyl);3-Bromo-4-fluorobenzeneacetonitrile;Benzeneacetonitrile, 3-bromo-4-fluoro-;3-Bromo-4-fluorophenylacetonitrile 95%;2-(3-Bromo-4-fluorophenyl)acetonitrile,96%
CBNumber
CB62657888
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
501420-63-9.mol
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3-Bromo-4-fluorobenzeneacetonitrile Property

Boiling point:
287.3±25.0℃ (760 Torr)
Density 
1.573±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
127.6±23.2℃
storage temp. 
2-8°C
form 
Solid
Appearance
Colorless to off-white Solid
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Safety

HazardClass 
6.1
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B692908
Product name
2-(3-Bromo-4-fluorophenyl)acetonitrile
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B692908
Product name
2-(3-Bromo-4-fluorophenyl)acetonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0004380
Product name
3-BROMO-4-FLUORO BENZYL CYANIDE
Purity
95.00%
Packaging
1G
Price
$765.23
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0004380
Product name
3-BROMO-4-FLUORO BENZYL CYANIDE
Purity
95.00%
Packaging
2.5G
Price
$1065.66
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0004380
Product name
3-BROMO-4-FLUORO BENZYL CYANIDE
Purity
95.00%
Packaging
5G
Price
$1295.03
Updated
2021/12/16
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3-Bromo-4-fluorobenzeneacetonitrile Chemical Properties,Usage,Production

Synthesis

78239-71-1

143-33-9

501420-63-9

The general procedure for the synthesis of 3-bromo-4-fluorophenylacetonitrile from 3-bromo-4-fluorobenzyl bromide and sodium cyanide was as follows: sodium cyanide (1.16 g, 22.4 mmol) was added to a solution of 2-bromo-4-(bromomethyl)-1-fluorobenzene (5.0 g, 18.7 mmol) in DMSO (80 mL), and the reaction was stirred for 18 hours at room temperature. After completion of the reaction, the reaction mixture was poured into ethyl acetate and washed four times with 5% NaCl solution. The organic layer was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product as an oil. Purification by silica gel column chromatography afforded 3-bromo-4-fluorophenylacetonitrile as a light amber oil (3.6 g, 75% yield).LC/MS analytical conditions: gradient elution with 90% CH3CN/H2O over 10 min over 5 min, retention time 2.57 min, m/z 214, 216 (M + H).1H NMR (400 MHz. CDCl3) δ ppm: 3.73 (s, 2H), 7.15 (t, J = 8.40 Hz, 1H), 7.20-7.32 (m, 1H), 7.56 (dd, J = 6.25, 2.35 Hz, 1H).

References

[1] Patent: WO2009/69044, 2009, A1. Location in patent: Page/Page column 97-98

3-Bromo-4-fluorobenzeneacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-4-fluorobenzeneacetonitrile Suppliers

Canada 1 China 39 India 2 United Kingdom 2 United States 5 Global 49
Alfa Aesar
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400-6106006
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021-67582001/03/05
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saleschina@alfa-asia.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
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sales8178@energy-chemical.com
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China
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
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info@chemlin.com.cn
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China
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16077
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9ding chemical ( Shanghai) Limited
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4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
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China
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
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13816107857
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qq: 276312098
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sales@fortunechem-sh.com
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China
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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Shanghai Yongye Biotechnology Co., Ltd.
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86-021-61559134 15921386130
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021-55068248
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3423497944@qq.com
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
ProdList
131957
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58
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
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China
ProdList
2952
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58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
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View Lastest Price from 3-Bromo-4-fluorobenzeneacetonitrile manufacturers

Career Henan Chemical Co
Product
2-(3-Bromo-4-fluorophenyl)acetonitrile 501420-63-9
Price
US $1.00/g
Min. Order
1g
Purity
Min98%HPLC
Supply Ability
g/kg/ton
Release date
2020-01-09

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