3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole
- Product Name
- 3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole
- CAS No.
- 34605-66-8
- Chemical Name
- 3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole
- Synonyms
- 3-(2,5-diMethylpyrrolyl)-1-Methylpyrazole;3-(2,5-diMethyl-pyrrol-1-yl)-1-Methyl-1H-pyrazole;3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole;1H-Pyrazole, 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-
- CBNumber
- CB62658517
- Molecular Formula
- C10H13N3
- Formula Weight
- 175.23
- MOL File
- 34605-66-8.mol
3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole Property
- Boiling point:
- 307.8±27.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.86±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- B431093
- Product name
- 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 2606AQ
- Product name
- 3-(2,5-DIMETHYL-1H-PYRROL-1-YL)-1-METHYL-1H-PYRAZOLE
- Packaging
- 1g
- Price
- $762.8
- Updated
- 2021/12/16
- Product number
- CM252371
- Product name
- 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- CD11139160
- Product name
- 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $376
- Updated
- 2021/12/16
- Product number
- 34605668
- Product name
- 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
- Packaging
- 1g
- Price
- $387.6
- Updated
- 2021/12/16
3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole Chemical Properties,Usage,Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 1224, 1984 DOI: 10.1021/jo00181a018
Synthesis
110-13-4
1904-31-0
34605-66-8
The general procedure for the synthesis of 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole from 2,5-hexanedione and N-methyl-3-aminopyrazole was as follows: according to step 3-i of Scheme 3, 1-methyl-1H-pyrazol-3-amine (compound 1007, 2.8 g, 28.8 mmol) and 2,5-hexanedione (3.38 mL , 28.8 mmol) were dissolved in 50 mL of toluene. P-toluenesulfonic acid (1.4 mmol) was added, the reaction mixture was heated to reflux, and the water generated by the reaction was collected in a Dean-Stark manifold. When no more water was generated (about 4 hours), the reaction mixture was cooled and the solvent evaporated. The residue was purified by silica gel column chromatography using dichloromethane as eluent to give an oily product which solidified to a solid after standing. The solid was broken up, suspended in hexane, stirred vigorously for 1 hour and collected by filtration. 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole (compound 1008, 5.0 g, 98% yield) was finally obtained as a white powder. It was characterized by the following data: ESMS (M + 1) = 175; 1H-NMR (CDCl3) δ 7.38 (d, J = 4 Hz, 1H), 6.14 (d, J = 4 Hz, 1H), 5.84 (s, 2H), 3.95 (s, 3H), 2.09 (s, 6H).
References
[1] Patent: US2011/81316, 2011, A1. Location in patent: Page/Page column 15; 16
[2] Patent: US2016/229837, 2016, A1. Location in patent: Paragraph 0589; 0590; 0591
[3] Patent: US2009/264434, 2009, A1. Location in patent: Page/Page column 27; 43
[4] Patent: WO2016/131098, 2016, A1. Location in patent: Page/Page column 141
[5] Patent: EP2426135, 2012, A1. Location in patent: Page/Page column 116
3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2,5-diMethyl-1H-pyrrol-1-yl)-1-Methyl-1H-pyrazole Suppliers
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