N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE

Product Name: N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE
CAS No.: 121749-39-1
Chemical Name: N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE
Synonyms: de333;denspm;BENSPM;be3-3-3;DiethylnorsperMine;Bisethyl norspermine;N1,N11-Diethylnorspe;3,7,11,15-Tetraazaheptadecane;N1,N11-Diethylnorspermine4HCl;n(1),n(11)-diethylnorspermine
CBNumber: CB6265962
Molecular Formula: C13H32N4
Formula Weight: 244.42
MOL File: 121749-39-1.mol

More

Less

N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Property

Boiling point:: 357.1±10.0 °C(Predicted)
Density: 0.877±0.06 g/cm3(Predicted)
storage temp.: Store at RT
pka: 10.95±0.19(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 0468
Product name: N1,N11-Diethylnorsperminetetrahydrochloride
Packaging: 10
Price: $171
Updated: 2021/12/16

Tocris

Product number: 0468
Product name: N1,N11-Diethylnorsperminetetrahydrochloride
Packaging: 50
Price: $717
Updated: 2021/12/16

Usbiological

Product number: 460258
Product name: N1,N11-Diethylnorspermine
Packaging: 10mg
Price: $403
Updated: 2021/12/16

Usbiological

Product number: 255932
Product name: N1,N11-Diethylnorspermine tetrahydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008719
Product name: N1,N11-DIETHYLNORSPERMINE
Purity: 95.00%
Packaging: 5MG
Price: $500.56
Updated: 2021/12/16

More

Less

N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

N1,N11-Diethylnorspermine (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[1][2][3][4][5][6].

Biological Activity

Highly potent inducer of spermidine/spermine N 1 -acetyltransferase, able to increase enzyme activity 200-1000 fold.

in vivo

N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line^[1].
N1,N11-Diethylnorspermine (120-360 mg/kg, s.c., 4 days) results in prolonged inhibition of tumor growth and long-term tumor regressions in nude athymic mice with MALME-3M melanoma xenografts^[5].
N1,N11-Diethylnorspermine (12.5-50 mg/kg, i.v., 5 days) is well tolerated and induces no physical signs in CD rats^[6].

IC 50

Caspase 3

References

[1] Schipper RG, et al. Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells. Prostate. 2000 Sep 1;44(4):313-21. DOI:10.1002/1097-0045(20000901)44:43.0.co;2-d
[2] Holst CM, et al. Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line. Anticancer Drugs. 2008 Oct;19(9):871-83. DOI:10.1097/CAD.0b013e32830f902b
[3] Jiang R, et al. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma. Int J Oncol. 2007 Aug;31(2):431-40. PMID:17611701
[4] Jiang R, et al. Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells. Cancer Biol Ther. 2007 Oct;6(10):1644-8. DOI:10.4161/cbt.6.10.4800
[5] Bernacki RJ, et al. Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. Clin Cancer Res. 1995 Aug;1(8):847-57. PMID:9816054
[6] Kanter PM, et al. Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs. Anticancer Drugs. 1994 Aug;5(4):448-56. DOI:10.1097/00001813-199408000-00010

N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE Suppliers

China 8 Europe 1 Germany 3 United Kingdom 2 United States 4 Global 18

BIOTREND GmbH

Tel: --
Fax: --
Email: jaeger@biotrend.com
Country: Germany
ProdList: 249
Advantage: 65

BIOTREND Chemicals AG

Tel: --
Fax: --
Email: info@biotrend.ch
Country: Germany
ProdList: 1250
Advantage: 62

Service Chemical Inc.

Tel: --
Fax: --
Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

121749-39-1, N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDERelated Search:

N,N'-BIS(3-AMINOPROPYL)-1,3-PROPANEDIAMINE N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE

denspm

n(1),n(11)-diethylnorspermine

n(sup1),n(sup11)-bis(ethyl)norspermine

n(sup1),n(sup11)-diethylnorspermine

n,n’-bis(3-(ethylamino)propyl)-3-propanediamine

N',N''-DIETHYLNORSPERMINE TETRAHYDROCHLORIDE

N,N'-BIS[3-(ETHYLAMINO)PROPYL]-1,3-PROPANEDIAMINE TETRAHYDROCHLORIDE

N1,N11-Diethylnorspermine4HCl

N1,N11-Diethylnorspermine tetrahydrochloride

3,7,11,15-Tetraazaheptadecane

Bisethyl norspermine

N,N'-(Trimethylenebisiminobistrimethylene)bis(ethanamine)

N,N''-Trimethylenebis(N'-ethylpropane-1,3-diamine)

BENSPM

DiethylnorsperMine

be3-3-3

de333

N1,N11-Diethylnorspe

1,3-Propanediamine,N1,N3-bis[3-(ethylamino)propyl]-

121749-39-1

C13H32N44HCl

Miscellaneous Enzyme