5-BroMo-1H-indole-2-carbonitrile

Product Name: 5-BroMo-1H-indole-2-carbonitrile
CAS No.: 902772-13-8
Chemical Name: 5-BroMo-1H-indole-2-carbonitrile
Synonyms: 5-BroMo-1H-indole-2-carbonitrile;1H-Indole-2-carbonitrile, 5-bromo-
CBNumber: CB62661405
Molecular Formula: C9H5BrN2
Formula Weight: 221.05
MOL File: 902772-13-8.mol

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5-BroMo-1H-indole-2-carbonitrile Property

Boiling point:: 405.9±25.0 °C(Predicted)
Density: 1.74±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.95±0.30(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B994015
Product name: 5-Bromo-1H-indole-2-carbonitrile
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143413
Product name: 5-Bromo-1H-indole-2-carbonitrile
Packaging: 500mg
Price: $725
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143413
Product name: 5-Bromo-1H-indole-2-carbonitrile
Packaging: 1g
Price: $900
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143413
Product name: 5-Bromo-1H-indole-2-carbonitrile
Packaging: 2g
Price: $1300
Updated: 2021/12/16

Matrix Scientific

Product number: 119837
Product name: 5-Bromo-1H-indole-2-carbonitrile
Purity: 95+%
Packaging: 5g
Price: $1764
Updated: 2021/12/16

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5-BroMo-1H-indole-2-carbonitrile Chemical Properties,Usage,Production

Synthesis

877371-97-6

902772-13-8

The general procedure for the synthesis of 5-bromo-1H-indole-2-carboxamide from 5-bromo-1H-indole-2-carbonitrile was as follows: 5-bromo-1H-indole-2-carboxamide (0.68 mg, 2.84 mmol) was suspended in toluene (20 mL). Phosphoryl chloride (1.326 mL, 14.22 mmol) was added slowly dropwise via syringe under stirring. The reaction mixture was heated to reflux and maintained for 1.5 hours. Upon completion of the reaction, the mixture was poured into saturated sodium bicarbonate solution and quenched. The aqueous phase was extracted twice with dichloromethane (50 mL x 2). The organic phases were combined, washed with brine (20 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (using a Biotage 25 g silica gel column eluting with a 0-5% ethyl acetate/dichloromethane gradient) to afford 5-bromo-1H-indole-2-carbonitrile (0.408 g, 1.85 mmol, 65% yield) as a tan solid. The mass spectrum (ESI, negative ion mode) showed m/z 219/221.

References

[1] Patent: WO2006/77367, 2006, A1. Location in patent: Page/Page column 120
[2] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 312; 313

5-BroMo-1H-indole-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BroMo-1H-indole-2-carbonitrile Suppliers

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902772-13-8, 5-BroMo-1H-indole-2-carbonitrileRelated Search:

5-BroMo-1H-indole-2-carbonitrile

1H-Indole-2-carbonitrile, 5-bromo-

902772-13-8