2-(TRIFLUOROACETYL)CYCLOHEXANONE
- Product Name
- 2-(TRIFLUOROACETYL)CYCLOHEXANONE
- CAS No.
- 387-89-3
- Chemical Name
- 2-(TRIFLUOROACETYL)CYCLOHEXANONE
- Synonyms
- AKOS B029513;2-(TRIFLUOROACETYL)CYCLOHEXANONE;2-(trifluoroacetyl)cyclohexan-1-one;2-(2,2,2-trifluoroacetyl)cyclohexanone;Cyclohexanone, 2-(2,2,2-trifluoroacetyl)-;2-(2,2,2-trifluoroethanoyl)cyclohexan-1-one
- CBNumber
- CB6266196
- Molecular Formula
- C8H9F3O2
- Formula Weight
- 194.15
- MOL File
- 387-89-3.mol
2-(TRIFLUOROACETYL)CYCLOHEXANONE Property
- Boiling point:
- 219.3±40.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.80±0.20(Predicted)
- form
- liquid
- color
- Light yellow
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T793713
- Product name
- 2-(2,2,2-Trifluoroacetyl)cyclohexanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC904873
- Product name
- 2-(Trifluoroacetyl)cyclohexanone
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- PC904873
- Product name
- 2-(Trifluoroacetyl)cyclohexanone
- Packaging
- 5g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- W5936
- Product name
- 2-(Trifluoroacetyl)cyclohexanone
- Packaging
- 100mg
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 090506
- Product name
- 2-(2,2,2-Trifluoroacetyl)cyclohexanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $227
- Updated
- 2021/12/16
2-(TRIFLUOROACETYL)CYCLOHEXANONE Chemical Properties,Usage,Production
Uses
2-(2,2,2-Trifluoroacetyl)cyclohexanone is a useful reactant for the synthesis of fluorinated 1-?desazapurines.
Synthesis
383-63-1
108-94-1
387-89-3
GENERAL PROCEDURE: In a dry Schlenk tube, NaH (6.0 mmol) was stirred with ethyl trifluoroacetate (6.0 mmol) in THF (5 mL) for 10 minutes at room temperature under argon protection. Subsequently, a THF (5 mL) solution of cyclohexanone (5.0 mmol) was added dropwise to the above mixture at 0 °C and under argon protection. The reaction mixture was stirred at the set temperature for 2-6 h. After that, it was cooled to 0 °C again and the reaction was quenched with 6 mL of 1 mol/L HCl solution. After continued stirring for 15 min, the reaction mixture was neutralized with saturated NaHCO3 solution. After conventional post-treatment, the residue was purified by silica gel column chromatography to afford the target product 2-(trifluoroacetyl)cyclohexanone.
References
[1] Tetrahedron, 2014, vol. 70, # 31, p. 4668 - 4674
[2] Magnetic Resonance in Chemistry, 1993, vol. 31, # 4, p. 323 - 328
[3] Journal of the American Chemical Society, 1953, vol. 75, p. 4753
[4] New Journal of Chemistry, 2007, vol. 31, # 6, p. 936 - 946
[5] RSC Advances, 2016, vol. 6, # 46, p. 40277 - 40286
2-(TRIFLUOROACETYL)CYCLOHEXANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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