Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate

Product Name: Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate
CAS No.: 24730-88-9
Chemical Name: Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate
Synonyms: Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate;1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-methyl-, ethyl ester
CBNumber: CB62664466
Molecular Formula: C12H20O4
Formula Weight: 228.28
MOL File: 24730-88-9.mol

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Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate Property

Boiling point:: 297.0±40.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 188657
Product name: Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate
Packaging: 500mg
Price: $1200
Updated: 2021/12/16

Matrix Scientific

Product number: 188657
Product name: Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate
Packaging: 1g
Price: $1800
Updated: 2021/12/16

Ambeed

Product number: A108089
Product name: Ethyl8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate
Purity: 98%
Packaging: 100mg
Price: $18
Updated: 2021/12/16

Ambeed

Product number: A108089
Product name: Ethyl8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate
Purity: 98%
Packaging: 250mg
Price: $30
Updated: 2021/12/16

Ambeed

Product number: A108089
Product name: Ethyl8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate
Purity: 98%
Packaging: 1g
Price: $62
Updated: 2021/12/16

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Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate Chemical Properties,Usage,Production

Synthesis

1489-97-0

74-88-4

24730-88-9

Ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate was synthesized as follows: n-butyllithium (n-BuLi, 1.6 eq.) was added slowly and dropwise to an anhydrous THF (1 M) solution of diisopropylamine (DIA, 1.2 eq.) over 20 min at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and further cooled to -78 °C. Subsequently, a solution of ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate (1 eq.) in THF (1 M) was added slowly and dropwise over 30 minutes, followed by the addition of iodomethane (3 eq.). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was diluted with brine and extracted with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The filtrate was concentrated to afford the target product ethyl 8-methyl-1,4-dioxaspiro[4.5]decane-8-carboxylate in 100% yield. The product was characterized by 1H NMR (400 MHz, CDCl3) with the following chemical shifts δ (ppm): 4.16 (q, J=7.1 Hz, 2H), 3.95 (s, 4H), 2.19-2.11 (m, 2H), 1.72-1.57 (m, 4H), 1.57-1.45 (m, 2H), 1.30-1.24 (m, 3H ), 1.20 (s, 3H).

References

[1] Patent: US2016/96841, 2016, A1. Location in patent: Paragraph 0332
[2] Patent: WO2018/13486, 2018, A1. Location in patent: Page/Page column 19
[3] Patent: US2009/253677, 2009, A1. Location in patent: Page/Page column 70
[4] Patent: CN105566324, 2016, A. Location in patent: Paragraph 0337; 0338; 0339; 0340
[5] Patent: US2009/275574, 2009, A1. Location in patent: Page/Page column 21

Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate Suppliers

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Ethyl 8-Methyl-1,4-dioxa-spiro[4,5]decane-8-carboxylate

1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-methyl-, ethyl ester

24730-88-9