2-Chloro-5-nitroquinoline
- Product Name
- 2-Chloro-5-nitroquinoline
- CAS No.
- 13067-94-2
- Chemical Name
- 2-Chloro-5-nitroquinoline
- Synonyms
- 2-Chloro-5-nitroquinoline;Quinoline, 2-chloro-5-nitro-;2-chloro-5-nitro-quinoline - [C82256]
- CBNumber
- CB62665342
- Molecular Formula
- C9H5ClN2O2
- Formula Weight
- 208.6
- MOL File
- 13067-94-2.mol
2-Chloro-5-nitroquinoline Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Methanol, Ethyl Acetate
- form
- Solid
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374695
- Product name
- 2-Chloro-5-nitroquinoline
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- C374695
- Product name
- 2-Chloro-5-nitroquinoline
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- HCH0363574
- Product name
- 2-CHLORO-5-NITROQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.88
- Updated
- 2021/12/16
- Product number
- 50322
- Product name
- 2-Chloro-5-nitroquinoline
- Packaging
- 5G
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- CD11297438
- Product name
- 2-Chloro-5-nitroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
2-Chloro-5-nitroquinoline Chemical Properties,Usage,Production
Uses
2-Chloro-5-nitroquinoline is used in the synthesis of potent, orally active corticotropin-releasing factor-1 receptor antagonists.
Synthesis
6938-27-8
13067-94-2
General method: 5-Nitroquinolin-2(1H)-one (9a) (1.0 eq.) or analog (9b) (1.0 eq.) was dissolved in 1,2-dichloroethane (1,2-DCE), phosphorus oxychloride (POCl3) (2.0 eq.) was added, and the reaction was stirred for 12 hr at 80 °C. Upon completion of the reaction, the solvent and unreacted reagents were removed by evaporation to give the product 2-chloro-5-nitroquinoline (14a) or the like (14b). SPECIFIC EXAMPLE: The reaction was carried out according to the general method described above using 5-nitroquinolin-2(1H)-one (9a) (100.0 mg, 0.50 mmol) and phosphorus oxychloride (POCl3) (0.09 mL, 1.0 mmol) to give 2-chloro-5-nitroquinoline (14a) (78.0 mg) in 75% yield.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 151, p. 462 - 481
2-Chloro-5-nitroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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