JNJ31001074AAC

Product Name: JNJ31001074AAC
CAS No.: 1103522-80-0
Chemical Name: JNJ31001074AAC
Synonyms: JNJ31001074AAC;JNJ-31001074AAC;JNJ 31001074AAC;Bavisant (dihydrochloride hydrate);JNJ-31001074AAC; JNJ 31001074AAC; JNJ31001074AAC;(4-Cyclopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone dihydrochloride hydrate
CBNumber: CB62666596
Molecular Formula: C19H30ClN3O3
Formula Weight: 383.92
MOL File: 1103522-80-0.mol

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JNJ31001074AAC Property

storage temp.: Store at -20°C
solubility: Water: ≥ 50 mg/mL (118.94 mM); DMSO: ≥ 1 mg/mL (2.38 mM)
form: Powder
color: White to pink

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1459
Product name: Bavisantdihydrochloridehydrate
Purity: 99.60%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ChemScene

Product number: CS-1459
Product name: Bavisantdihydrochloridehydrate
Purity: 99.60%
Packaging: 10mg
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-1459
Product name: Bavisantdihydrochloridehydrate
Purity: 99.60%
Packaging: 50mg
Price: $1008
Updated: 2021/12/16

ChemScene

Product number: CS-1459
Product name: Bavisantdihydrochloridehydrate
Purity: 99.60%
Packaging: 100mg
Price: $1680
Updated: 2021/12/16

Crysdot

Product number: CD31004572
Product name: Bavisantdihydrochloridehydrate
Purity: 98+%
Packaging: 5mg
Price: $151
Updated: 2021/12/16

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JNJ31001074AAC Chemical Properties,Usage,Production

Uses

Bavisant dihydrochloride hydrate (JNJ31001074AAC) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant dihydrochloride hydrate can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].

in vivo

Bavisant dihydrochloride hydrate increases acetylcholine levels in rat frontal cortex^[4].

IC 50

H₃ receptor

References

[1] Hudkins RL, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92. DOI:10.1021/jm200401v
[2] Weisler RH, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. DOI:10.2165/11631990-000000000-00000
[3] Ghoshal A, et al. Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem. 2018 May 25;152:148-159. DOI:10.1016/j.ejmech.2018.04.020
[4] Ghamari N, et al. Histamine H3 receptor antagonists/inverse agonists: Where do they go Pharmacol Ther. 2019 Aug;200:69-84. DOI:10.1016/j.pharmthera.2019.04.007

JNJ31001074AAC Preparation Products And Raw materials

Raw materials

Preparation Products

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JNJ31001074AAC Suppliers

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1103522-80-0, JNJ31001074AACRelated Search:

Bavisant (dihydrochloride hydrate)

JNJ 31001074AAC

JNJ31001074AAC

JNJ-31001074AAC

JNJ-31001074AAC; JNJ 31001074AAC; JNJ31001074AAC

(4-Cyclopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone dihydrochloride hydrate

1103522-80-0

C19H27N3O22HClH2O