ChemicalBook > CAS DataBase List > BMX-IN-1

BMX-IN-1

Product Name
BMX-IN-1
CAS No.
1431525-23-3
Chemical Name
BMX-IN-1
Synonyms
henyl]-;BMX-IN-1;BMX inhibitor 1;BMX-IN-1 USP/EP/BP;BMX kinase inhibitor;BMX-IN-1 (BMX kinase inhibitor;6]naphthyridin-1(2H)-yl)phenyl)acrylamide;N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1;inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1;N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide
CBNumber
CB62666602
Molecular Formula
C29H24N4O4S
Formula Weight
524.59
MOL File
1431525-23-3.mol
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BMX-IN-1 Property

Density 
1.397±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
form 
solid
pka
7.77±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05021
Product name
BMX-IN-1 - CAS 1431525-23-4 - Calbiochem
Packaging
10mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
19165
Product name
BMX-IN-1
Purity
≥95%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19165
Product name
BMX-IN-1
Purity
≥95%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
19165
Product name
BMX-IN-1
Purity
≥95%
Packaging
5mg
Price
$214
Updated
2024/03/01
Tocris
Product number
5123
Product name
BMX-IN-1
Purity
≥98%(HPLC)
Packaging
5
Price
$160
Updated
2021/12/16
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BMX-IN-1 Chemical Properties,Usage,Production

Description

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).

target

BMX Kinase

storage

Store at -20°C

BMX-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMX-IN-1 Suppliers

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1431525-23-3, BMX-IN-1Related Search:


  • 6]naphthyridin-1(2H)-yl)phenyl)acrylamide
  • BMX KINASE INHIBITOR;N-(2-METHYL-5-(9-(4-(METHYLSULFONAMIDO)PHENYL)-2-OXOBENZO[H][1;6]NAPHTHYRIDIN-1(2H)-YL)PHENYL)ACRYLAMIDE
  • N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1
  • BMX kinase inhibitor
  • BMX-IN-1
  • N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide
  • N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
  • henyl]-
  • BMX-IN-1 (BMX kinase inhibitor
  • BMX inhibitor 1
  • 2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-
  • BMX-IN-1 USP/EP/BP
  • BMX-INQ: What is BMX-IN Q: What is the CAS Number of BMX-IN Q: What is the storage condition of BMX-IN
  • inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1
  • 1431525-23-3