ZP 1609 Hydrochloride
- Product Name
- ZP 1609 Hydrochloride
- CAS No.
- 943133-81-1
- Chemical Name
- ZP 1609 Hydrochloride
- Synonyms
- GAP134 Hydrochloride;ZP1609 Hydrochloride;ZP 1609 Hydrochloride;ZP-1609 Hydrochloride;GAP 134 Hydrochloride;GAP-134 (Hydrochloride);Danegaptide Hydrochloride;GAP-134 HYDROCHLORIDE, >98%;Danegaptide hydrochloride salt;Danegaptide (GAP-134) hydrochloride
- CBNumber
- CB62666622
- Molecular Formula
- C14H18ClN3O4
- Formula Weight
- 327.76342
- MOL File
- 943133-81-1.mol
ZP 1609 Hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:55.0(Max Conc. mg/mL);167.81(Max Conc. mM)
H2O:75.0(Max Conc. mg/mL);228.83(Max Conc. mM) - form
- Powder
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-1101
- Product name
- DanegaptideHydrochloride
- Purity
- 99.75%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-1101
- Product name
- DanegaptideHydrochloride
- Purity
- 99.75%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-1101
- Product name
- DanegaptideHydrochloride
- Purity
- 99.75%
- Packaging
- 25mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- orb611743
- Product name
- GAP-134 hydrochloride
- Packaging
- 10mg
- Price
- $598.4
- Updated
- 2021/12/16
- Product number
- CS-1101
- Product name
- DanegaptideHydrochloride
- Purity
- 99.75%
- Packaging
- 50mg
- Price
- $750
- Updated
- 2021/12/16
ZP 1609 Hydrochloride Chemical Properties,Usage,Production
Description
GAP-134 Hcl (Danegaptide, ZP 1609), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. IC50 value: Target: gap junction Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.
References
References:[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554
ZP 1609 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
ZP 1609 Hydrochloride Suppliers
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