ZP 1609 Hydrochloride

Product Name: ZP 1609 Hydrochloride
CAS No.: 943133-81-1
Chemical Name: ZP 1609 Hydrochloride
Synonyms: GAP134 Hydrochloride;ZP1609 Hydrochloride;ZP 1609 Hydrochloride;ZP-1609 Hydrochloride;GAP 134 Hydrochloride;GAP-134 (Hydrochloride);Danegaptide Hydrochloride;GAP-134 HYDROCHLORIDE, >98%;Danegaptide hydrochloride salt;Danegaptide (GAP-134) hydrochloride
CBNumber: CB62666622
Molecular Formula: C14H18ClN3O4
Formula Weight: 327.76342
MOL File: 943133-81-1.mol

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ZP 1609 Hydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO:55.0(Max Conc. mg/mL);167.81(Max Conc. mM)
H2O:75.0(Max Conc. mg/mL);228.83(Max Conc. mM)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-1101
Product name: DanegaptideHydrochloride
Purity: 99.75%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-1101
Product name: DanegaptideHydrochloride
Purity: 99.75%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-1101
Product name: DanegaptideHydrochloride
Purity: 99.75%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611743
Product name: GAP-134 hydrochloride
Packaging: 10mg
Price: $598.4
Updated: 2021/12/16

ChemScene

Product number: CS-1101
Product name: DanegaptideHydrochloride
Purity: 99.75%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

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ZP 1609 Hydrochloride Chemical Properties,Usage,Production

Description

GAP-134 Hcl (Danegaptide, ZP 1609), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability. IC50 value: Target: gap junction Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Gap junction modifier GAP-134, showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. GAP-134 is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.

References

References:[1]. De Vuyst E, Boengler K, Antoons G, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [2]. Laurent G, Leong-Poi H, Mangat I, et al. Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs. Circ Arrhythm Electrophysiol. 2009 Apr;2(2):171-8. [3]. Hennan JK, Swillo RE, Morgan GA, et al. GAP-134 ([2S,4R]-1-[2-aminoacetyl]4-benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther. 2009 Sep;14(3):207-14. [4]. Rossman EI, Liu K, Morgan GA, et al. The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. [5]. Eugene L. Piatnitski Cheklera, John A. Buterab, Li Dib, Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents. Bioorganic & Medicinal Chemistry Letters. 2009,19(16): 4551-4554

ZP 1609 Hydrochloride Preparation Products And Raw materials

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Preparation Products

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ZP 1609 Hydrochloride Suppliers

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943133-81-1, ZP 1609 HydrochlorideRelated Search:

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Danegaptide hydrochloride salt

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ZP-1609,ZP 1609,GAP 134,Danegaptide,antiarrhythmic,inhibit,dipeptide,Danegaptide Hydrochloride,Gap Junction Protein,ZP1609,GAP134,GAP-134,Cardioprotective,orally,Inhibitor

(2S,4R)-4-Benzamido-1-glycylpyrrolidine-2-carboxylic acid hydrochloride

943133-81-1

C14H17N3O4ClH