R-1530

ChemicalBook > CAS DataBase List > R-1530

Product Name: R-1530
CAS No.: 882531-87-5
Chemical Name: R-1530
Synonyms: R1530;R 1530;R-1521;R-1530;CS-1111;R 1530, >=98%;R 1530; R-1530;5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine;5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo[3,4-b][1,4]benzodiazepine;Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-
CBNumber: CB62666677
Molecular Formula: C18H14ClFN4O
Formula Weight: 356.78
MOL File: 882531-87-5.mol

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R-1530 Property

Boiling point:: 550.9±50.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 17.23±0.40(Predicted)
color: white to yellow to light brown

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1074
Product name: R1530
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $423
Updated: 2022/05/15

Cayman Chemical

Product number: 15255
Product name: R 1530
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15255
Product name: R 1530
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 15255
Product name: R 1530
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 15255
Product name: R 1530
Purity: ≥98%
Packaging: 25mg
Price: $420
Updated: 2024/03/01

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R-1530 Chemical Properties,Usage,Production

Uses

R 1530 is a multi-kinase inhibitor. It exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2. It also binds VEGFR-2, FGFR1 and PDGFRβ. It displays antiproliferative activity in vitro and inhibits mitosis and angiogenesis.

Biological Activity

R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.

R-1530 Preparation Products And Raw materials

Raw materials

Preparation Products

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R-1530 Suppliers

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882531-87-5