Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-

Product Name: Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
CAS No.: 1225278-64-7
Chemical Name: Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
Synonyms: Oliceridine Impurity 20;1,3-Dioxane-5,5-dimethanol,2-(6-methoxyphenyl)-;2-chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine;Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
CBNumber: CB62666738
Molecular Formula: C11H5ClF2N2O3
Formula Weight: 286.62
MOL File: 1225278-64-7.mol

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Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M2313
Product name: Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
Packaging: 250mg
Price: $154
Updated: 2021/12/16

AK Scientific

Product number: 3169AH
Product name: 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine
Packaging: 100mg
Price: $189
Updated: 2021/12/16

AK Scientific

Product number: 3169AH
Product name: 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine
Packaging: 250mg
Price: $273
Updated: 2021/12/16

ChemScene

Product number: CS-M2313
Product name: Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-
Packaging: 1g
Price: $330
Updated: 2021/12/16

AK Scientific

Product number: 3169AH
Product name: 2-Chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine
Packaging: 1g
Price: $601
Updated: 2021/12/16

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Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Chemical Properties,Usage,Production

Synthesis

17368-12-6

2105-61-5

1225278-64-7

Sodium hydride (136 mg, 3.4 mmol, 60% mineral oil dispersion) was added batchwise to an anhydrous N,N-dimethylformamide (DMF, 38 mL) solution of 2-chloro-4-hydroxypyridine (2 g, 15.4 mmol) under argon protection. The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, a solution of 2,4,5-trifluoronitrobenzene (626 mg, 3.1 mmol) in anhydrous DMF (7.6 mL) was added dropwise and the reaction system was warmed up to 90 °C under argon protection with continuous stirring for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and stirring was continued overnight. The solvent was removed by distillation under reduced pressure and the crude product was partitioned with 50 mL of water and 50 mL of ethyl acetate (EtOAc). The aqueous phase was extracted with ethyl acetate (3 x 50 mL) and the combined organic phases were washed with saturated saline and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the target compound 2-chloro-4-(2,5-difluoro-4-nitrophenoxy)pyridine (3.57 g, 81% yield) was purified by silica gel column chromatography (eluent: hexane/ethyl acetate gradient). The product was characterized by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 8.43-8.33 (m, 2H), 7.85-7.79 (m, 1H), 7.33 (d, 1H), 7.20-7.18 (m, 1H); MS (ESI) m/z: 287.0 [M+H]+.

References

[1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 73-74
[2] Patent: WO2011/137342, 2011, A1. Location in patent: Page/Page column 31
[3] Patent: WO2013/78295, 2013, A2. Location in patent: Paragraph 00171
[4] Patent: WO2014/145004, 2014, A1. Location in patent: Paragraph 0100
[5] Patent: US2014/315917, 2014, A1. Location in patent: Paragraph 0312

Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)- Suppliers

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1225278-64-7, Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-Related Search:

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Oliceridine Impurity 20

1225278-64-7

C11H5ClF2N2O3