ChemicalBook > CAS DataBase List > FG 2216

FG 2216

Product Name
FG 2216
CAS No.
223387-75-5
Chemical Name
FG 2216
Synonyms
BIQ;IOX-3;YM 311;FG2216;FG-2216;FG 2216;CS-1687;FG-2216(IOX3;FG-2216 - YM 311;FG2216;FG-2216;FG 2216
CBNumber
CB62666905
Molecular Formula
C12H9ClN2O4
Formula Weight
280.66
MOL File
223387-75-5.mol
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FG 2216 Property

Boiling point:
670.6±55.0 °C(Predicted)
Density 
1.571±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
form 
powder
pka
3.20±0.10(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1811
Product name
BIQ
Purity
≥98% (HPLC)
Packaging
5mg
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1811
Product name
BIQ
Purity
≥98% (HPLC)
Packaging
25mg
Price
$639
Updated
2024/03/01
Cayman Chemical
Product number
18382
Product name
FG-2216
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18382
Product name
FG-2216
Purity
≥98%
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
18382
Product name
FG-2216
Purity
≥98%
Packaging
10mg
Price
$257
Updated
2024/03/01
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FG 2216 Chemical Properties,Usage,Production

Description

FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.

Uses

FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.

Biochem/physiol Actions

BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.

References

1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.

FG 2216 Preparation Products And Raw materials

Raw materials

Preparation Products

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FG 2216 Suppliers

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View Lastest Price from FG 2216 manufacturers

Career Henan Chemical Co
Product
FG 2216 223387-75-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

223387-75-5, FG 2216Related Search:


  • FG 2216
  • FG2216
  • FG-2216
  • [[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid
  • FG 2216 (erythropoietic agent)
  • YM 311
  • (Z)-2-(((1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)(HYDROXY)METHYLENE)AMINO)ACETIC ACID
  • N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine
  • (N-(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid
  • FG2216;FG-2216;FG 2216
  • Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-
  • CS-1687
  • FG-2216(IOX3
  • FG-2216 - YM 311
  • BIQ
  • 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid
  • (1-Chloro-4-hydroxyisoquinoline-3-carbonyl)glycine
  • IOX-3
  • 223387-75-5
  • Inhibitors