SKLB 610

ChemicalBook > CAS DataBase List > SKLB 610

Product Name: SKLB 610
CAS No.: 1125780-41-7
Chemical Name: SKLB 610
Synonyms: CS-913;SKLB 710;SKLB 610;SKLB 610, >=98%;SKLB 610; SKLB-610;N-METHYL-4-(4-(3-(TRIFLUOROMETHYL)BENZAMIDO)PHENOXY)PICOLINAMIDE;N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide;N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]pyridine-2-carboxamide;2-Pyridinecarboxamide, N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]-;N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide SKLB 610
CBNumber: CB62667038
Molecular Formula: C21H16F3N3O3
Formula Weight: 415.37
MOL File: 1125780-41-7.mol

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SKLB 610 Property

Boiling point:: 500.9±50.0 °C(Predicted)
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Store at 4°C
solubility: insoluble in H2O; ≥20.75 mg/mL in DMSO; ≥23 mg/mL in EtOH with ultrasonic
form: solid
pka: 12.23±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21561
Product name: SKLB 610
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21561
Product name: SKLB 610
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 21561
Product name: SKLB 610
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 21561
Product name: SKLB 610
Packaging: 25mg
Price: $571
Updated: 2024/03/01

ApexBio Technology

Product number: A8237
Product name: SKLB610
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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SKLB 610 Chemical Properties,Usage,Production

Biological Activity

sklb610 is a selective inhibitor of vegfr with ic50 value of 2.2 μm [1].vegfr (vascular endothelial growth factor receptor) are receptors for vegf and plays an important role in stimulating cellular response by cooperating with vegf. it has been reported that vegfr abnormally expressed in a variety of cancers and its inhibitors has been regarded as a promising strategy in clinic [1, 2].sklb610 is a potent vegf induced vegf2 phosphorylation inhibitor. when tested with a panel of human cancer cell lines, sklb610 inhibited cell proliferation with ic50 value ranges from 2.2 μm to 25.6 μm. in huvecs, sklb610 showed inhibition on vegf-stimulated cell proliferation as well as vegfr2 phosphorylation, inhibited cell capillary tube formation in a dose-dependent manner [1]. the solubility of sklb610 in water, ethanol, ethyl acetate, 0.5% tween 80 and nanosuspension is 0.34 μg/ml, 16500 μg/ml, 380μg/ml, 23μg/ml and 103μg/ml [2, 3].in mouse model with hct116 subcutaneous xenograft, administration of sklb610 (12.5 mg/kg, 25 mg/kg and 50 mg/kg) for 10 days markedly delayed tumor growth in a concentration dependent manner. further, after 30 days treatment sklb610significantly suppressed tumor volume as 77.1 % at the dose of 50 mg/kg [1].

target

FGFR

References

[1]. cao, z.x., et al., sklb610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. cell physiol biochem, 2011. 27(5): p. 565-74.
[2]. luo, x., et al., pharmacokinetic studies of a novel multikinase inhibitor for treating cancer by hplc-uv. j chromatogr sci, 2013. 51(1): p. 17-20.
[3]. huang, y., et al., the preparation and evaluation of water-soluble sklb610 nanosuspensions with improved bioavailability. aaps pharmscitech, 2013. 14(3): p. 1236-43.

SKLB 610 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SKLB 610 manufacturers

Career Henan Chemical Co

Product: SKLB 610 1125780-41-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2018-08-08

1125780-41-7, SKLB 610Related Search:

SKLB 610

N-METHYL-4-(4-(3-(TRIFLUOROMETHYL)BENZAMIDO)PHENOXY)PICOLINAMIDE

N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide

SKLB 610, >=98%

N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide SKLB 610

SKLB 610 N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide

SKLB 710

N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]pyridine-2-carboxamide

SKLB 610; SKLB-610

CS-913

2-Pyridinecarboxamide, N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]-

1125780-41-7

Inhibitors