ChemicalBook > CAS DataBase List > AZD 4017

AZD 4017

Product Name
AZD 4017
CAS No.
1024033-43-9
Chemical Name
AZD 4017
Synonyms
AZD 4017;EOS-62043;AZD 4017 (AZD4017);AZD 4017, 10 mM in DMSO;AZD 4017,inhibit,AZD4017,Inhibitor,AZD-4017;(S)-2-(1-(5-(Cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid;{(3S)-1-[5-(Cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid;2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic Acid;3-Piperidineacetic acid, 1-[5-[(cyclohexylaMino)carbonyl]-6-(propylthio)-2-pyridinyl]-, (3S)-;(S)-2-(1-(5-(CYCLOHEXYLCARBAMOYL)-6-(PROPYLTHIO)PYRIDIN-2-YL)PIPERIDIN-3-YL) ACETIC ACID (AZD 4017)
CBNumber
CB62667043
Molecular Formula
C22H33N3O3S
Formula Weight
419.58
MOL File
1024033-43-9.mol
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AZD 4017 Property

Boiling point:
654.7±55.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
4.65±0.10(Predicted)
color 
Light yellow to yellow
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Crysdot
Product number
CD11363981
Product name
(S)-2-(1-(5-(Cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)aceticacid
Purity
95+%
Packaging
100mg
Price
$660
Updated
2021/12/16
Crysdot
Product number
CD11363981
Product name
(S)-2-(1-(5-(Cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)aceticacid
Purity
95+%
Packaging
250mg
Price
$1056
Updated
2021/12/16
Crysdot
Product number
CD11363981
Product name
(S)-2-(1-(5-(Cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)aceticacid
Purity
95+%
Packaging
1g
Price
$2640
Updated
2021/12/16
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AZD 4017 Chemical Properties,Usage,Production

Uses

AZD 4017 is a potent, selective 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) inhibitor, with an IC50 of 7 nM.

in vivo

Since AZD 4017 has lower potency against the mouse enzyme, only a limited number of preclinical pharmacodynamic measurements are performed. Increasing the dose further led to a maximal effect of approximately 70% inhibition at 1500 mg/kg, equivalent to 10×IC50 in the mouse, demonstrating the dose dependent inhibition of 11β-HSD1 by AZD 4017 in this model[1].

References

[1] Scott JS, et al. Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). J Med Chem. 2012 Jun 28;55(12):5951-64. DOI:10.1021/jm300592r

AZD 4017 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD 4017 Suppliers

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1024033-43-9, AZD 4017Related Search:


  • AZD 4017
  • (S)-2-(1-(5-(CYCLOHEXYLCARBAMOYL)-6-(PROPYLTHIO)PYRIDIN-2-YL)PIPERIDIN-3-YL) ACETIC ACID (AZD 4017)
  • 3-Piperidineacetic acid, 1-[5-[(cyclohexylaMino)carbonyl]-6-(propylthio)-2-pyridinyl]-, (3S)-
  • (S)-2-(1-(5-(Cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid
  • EOS-62043
  • AZD 4017 (AZD4017)
  • 2-[(3s)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]piperidin-3-yl]acetic Acid
  • AZD 4017,inhibit,AZD4017,Inhibitor,AZD-4017
  • AZD 4017, 10 mM in DMSO
  • {(3S)-1-[5-(Cyclohexylcarbamoyl)-6-(propylsulfanyl)pyridin-2-yl]piperidin-3-yl}acetic acid
  • 1024033-43-9