AZD3839

Product Name: AZD3839
CAS No.: 1227163-56-5
Chemical Name: AZD3839
Synonyms: AZD3839;(Rac)-AZD3839;AZD-3839;AZD 3839;4-Fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-1H-isoindol-3-amine;4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine;1H-Isoindol-3-amine, 4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-
CBNumber: CB62667311
Molecular Formula: C24H15F4N5
Formula Weight: 449.4
MOL File: 1227163-56-5.mol

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AZD3839 Property

Boiling point:: 574.9±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20° C
solubility: Soluble in DMSO
form: Powder
pka: 2.47±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A808145
Product name: AZD3839
Packaging: 50mg
Price: $875
Updated: 2021/12/16

ApexBio Technology

Product number: B3224
Product name: AZD3839
Packaging: 50mg
Price: $1103
Updated: 2021/12/16

ApexBio Technology

Product number: B3224
Product name: AZD3839
Packaging: 5mg
Price: $205
Updated: 2021/12/16

ApexBio Technology

Product number: B3224
Product name: AZD3839
Packaging: 10mg
Price: $315
Updated: 2021/12/16

ApexBio Technology

Product number: B3224
Product name: AZD3839
Packaging: 25mg
Price: $630
Updated: 2021/12/16

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AZD3839 Chemical Properties,Usage,Production

Uses

AZD3839 is a potent and selective inhibitor of human Beta-secretase 1 (BACE1).

Biological Activity

azd3839 is a novel inhibitor of bace1 with ic50 value of 4.8μm [1].azd3839 has been reported to inhibit human bace1 activity in a biochemical fret assay. in addition, azd3839 has also been reported to inhibit the release of sappβs from human sh-sy5y cells, mouse n2a cells and mouse and guinea pig primary cortical neurons. moreover, azd3839 has been revealed to effectively decrease the cerebrospinal fluid (csf), plasma, and brain aβ levels in guinea pig, mouse and non-human primate. azd3839 has also been revealed to decrease the levels of aβ40 secreted from c57bl/6 mouse primary cortical neurons, n2a cells (mouse neuroblastoma), and dunkin-hartley guinea pig primary cortical neurons, with ic50 values of 50.9, 32.2, and 24.8 nmol/liter, respectively [2].

target

BACE1

References

[1] sparve e1, quartino al1, luttgen m1, tunblad k1, teiling-gardlund a1, falting j1, alexander r1, kagstrom j1, sjodin l1, bulgak a1, al-saffar a1, bridgland-taylor m2, pollard c3, swedberg md4, vik t5, paulsson b1. prediction and modeling of effects on the qtc interval for clinical safety margin assessment, based on single ascending dose study data with azd3839. j pharmacol exp ther. 2014 jun 10.
[2] jeppsson f1, eketjäll s, janson j, karlström s, gustavsson s, olsson ll, radesäter ac, ploeger b, cebers g, kolmodin k, swahn bm, von berg s, bueters t, fälting j. discovery of azd3839, a potent and selective bace1 inhibitor clinical candidate for the treatment of alzheimer disease. j biol chem. 2012 nov 30;287(49):41245-57.

AZD3839 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD3839 Suppliers

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1227163-56-5, AZD3839Related Search:

Cyfluthrin FLONICAMID

AZD3839

4-Fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-1H-isoindol-3-amine

AZD-3839;AZD 3839

1H-Isoindol-3-amine, 4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1-[2-(trifluoromethyl)-4-pyridinyl]-

4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine

(Rac)-AZD3839

1227163-56-5

C24H15F4N5

inhibitor