Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

Product Name: Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-
CAS No.: 870544-59-5
Chemical Name: Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-
Synonyms: BPTU;CS-2758;BMS-646786;BPTU, 10 mM in DMSO;P2Y Antagonist II, BPTU;1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea;BPTU,antithrombotic,thrombosis,BMS 646786,P2Y Receptor,inhibit,BMS646786,Inhibitor;N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea;Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-
CBNumber: CB62668237
Molecular Formula: C23H22F3N3O3
Formula Weight: 445.43
MOL File: 870544-59-5.mol

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Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Property

Boiling point:: 426.3±45.0 °C(Predicted)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:34.29(Max Conc. mg/mL);76.98(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.67(Max Conc. mM)
DMF:15.0(Max Conc. mg/mL);33.67(Max Conc. mM)
Ethanol:29.77(Max Conc. mg/mL);66.83(Max Conc. mM)
form: A solid
pka: 12.59±0.70(Predicted)
color: White to off-white
InChI: 1S/C23H22F3N3O3/c1-22(2,3)17-7-4-5-9-19(17)31-20-18(8-6-14-27-20)29-21(30)28-15-10-12-16(13-11-15)32-23(24,25)26/h4-14H,1-3H3,(H2,28,29,30)
InChIKey: AHFLGPTXSIRAQK-UHFFFAOYSA-N
SMILES: FC(F)(F)Oc1ccc(cc1)NC(=O)Nc2c(nccc2)Oc3c(cccc3)C(C)(C)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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Cayman Chemical

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Tocris

Product number: 6078
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Updated: 2021/12/16

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Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Chemical Properties,Usage,Production

Uses

BPTU is a non-nucleotide antagonist of P2Y1 receptor. It blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents.

Biological Activity

Primary Target
P2Y1', 'Reversible: yes

in vivo

Uptake of BPTU from the peritoneal cavity is relatively rapid. Blood boron levels are maximal within 1 h after administration. After only 1 h, a boron tumor-to-blood ratio above 1 is found for BPTU in pigmented tumors, which is indicative of drug retention. This is not seen in the non-pigmented tumor variant, in which tumor boron levels closely follow blood levels. Up to 24 h, Borocaptate sodium (BSH) exhibits no selective retention in either tumor, but achieves higher maximum tumor boron concentrations than BPTU as a result of the administration of higher amounts of boron. During the tissue distribution phase, liver-to-kidney boron concentration ratios range from 2 to 4 for BSH and from 0.5 to 1 for BPTU^[2].

IC 50

P2Y1 Receptor

storage

Store at RT

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Suppliers

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View Lastest Price from Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- manufacturers

Career Henan Chemical Co

Product: Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- 870544-59-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

870544-59-5, Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-Related Search:

Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

BPTU

1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea

N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea

CS-2758

BMS-646786

BPTU,antithrombotic,thrombosis,BMS 646786,P2Y Receptor,inhibit,BMS646786,Inhibitor

BPTU, 10 mM in DMSO

P2Y Antagonist II, BPTU

870544-59-5

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