Necrosulfonamide
- Product Name
- Necrosulfonamide
- CAS No.
- 1360614-48-7
- Chemical Name
- Necrosulfonamide
- Synonyms
- 100318;CS-2351;NecrosulfonaMide;(E)-NECROSULFONAMIDE;(Z)-Necrosulfonamide;Necrosulfonamide (NSA);(2Z)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide;(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfaMoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylaMide;(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide;2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-
- CBNumber
- CB62669623
- Molecular Formula
- C18H15N5O6S2
- Formula Weight
- 461.47
- MOL File
- 1360614-48-7.mol
Necrosulfonamide Property
- Melting point:
- 200-204°C(dec.)
- Density
- 1.578±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml)
- form
- solid
- pka
- 6.37±0.40(Predicted)
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20844
- Product name
- Necrosulfonamide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 20844
- Product name
- Necrosulfonamide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 20844
- Product name
- Necrosulfonamide
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 20844
- Product name
- Necrosulfonamide
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 5025
- Product name
- Necrosulfonamide
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $458
- Updated
- 2021/12/16
Necrosulfonamide Chemical Properties,Usage,Production
Description
Necrosulfonamide (1360614-48-7) specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells.3 Binds to gasdermin D inhibiting pyroptosis and associated inflammatory cell death and sepsis.4 Rescues cells from TLR3 ligand-induced death.5
Uses
Necrosulfonamide is a necroptosis inhibitor. Necrosulfonamide is a pharmacological inhibitor of mixed lineage kinase domain-like protein (MLKL).
Definition
ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.
storage
Store at +4°C
References
1) Sun et al. (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase; Cell 148 213 2) Zhou et al. (2017) The degradation of mixed linage kinase domain-like protein promotes neuroprotection after ischemic brain injury; Oncotarget, 8 68393 3) Chen et al. (2017) CHAC1 degradation of glutathione enhances cysteine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-elF2α-ATF4 pathway; Oncotarget, 8 114588 4) Rathkey et al. (2018) Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis; Sci Immunol., 3 eaat2738 5) Cuchet-Lourenco et al. (2018) Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation; Science, 361 810
Necrosulfonamide Preparation Products And Raw materials
Raw materials
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