Cinacalcet Impurity D

ChemicalBook > CAS DataBase List > Cinacalcet Impurity D

Product Name: Cinacalcet Impurity D
CAS No.: 1271930-15-4
Chemical Name: Cinacalcet Impurity D
Synonyms: Cinacalcet USP RC B;CicalcetImpurityDHCl;CicalcetImpurity1HCl;Cinacalcet Impurity D;cinacalcet iMpurity 8;Cinacalcet Impurity D HCL;Cinacalcet tertiary amine;Cinacalcet USP Related Compound B;Cinacalcet Hydrochloride iMpuritX;Cinacalcet Impurity 5(Cinacalcet USP RC B)
CBNumber: CB62671079
Molecular Formula: C32H31F6N
Formula Weight: 543.59
MOL File: 1271930-15-4.mol

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Cinacalcet Impurity D Property

Boiling point:: 552.2±50.0 °C(Predicted)
Density: 1.203±0.06 g/cm3(Predicted)
pka: 8.40±0.50(Predicted)
InChIKey: BMWNEBVDXWCUKG-CRPMJUFNNA-N
SMILES: C(N([C@@H](C1=C2C(C=CC=C2)=CC=C1)C)CCCC1=CC=CC(C(F)(F)F)=C1)CCC1=CC=CC(C(F)(F)F)=C1 |&1:2,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T791425
Product name: N-[(3-Trifluoromethyl)phenyl)propyl]Cinacalcet
Packaging: 50mg
Price: $1320
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 53292
Product name: N-[(3-Trifluoromethyl)phenyl)propyl]Cinacalcet
Packaging: 50mg
Price: $2200
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 53292
Product name: N-[(3-Trifluoromethyl)phenyl)propyl]Cinacalcet
Packaging: 5mg
Price: $650
Updated: 2021/12/16

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Cinacalcet Impurity D Chemical Properties,Usage,Production

Description

Cinacalcet Impurity D is a potential byproduct or impurity in the synthesis of the drug. It is essential to study the properties and potential implications of Cinacalcet Impurity D for pharmaceutical research. Cinacalcet is a drug commonly used for the treatment of hyperparathyroidism in patients with chronic kidney disease.

Uses

N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet (Cinacalcet USP Related Compound B) is an impurity of Cinacalcet Hydrochloride (C441800). Cinacalcet is used in clinical trial in secondary hyperparathyroidism.

Preparation

Cinacalcet hydrochloride (11 g, 0.028 mol) in toluene (150 mL) was added to potassium carbonate (7.74 g, 0.056 mol) followed by 1-(3-bromopropyl)-3-(trifluoromethyl)benzene (14.95 g, 0.056 mol) under stirring at 25-30 °C. The reaction was heated and stirred at 110-111 °C for 48 h. Upon completion of the reaction (by TLC), the reaction was cooled and quenched with water (100 mL). The organic layer was separated, washed with water (100 mL), and concentrated under reduced pressure to obtain a thick oil. The crude oil was then purified by column chromatography on silica gel by eluting with chloroform to afford Cinacalcet Impurity D as a thick transparent oil.

Cinacalcet Impurity D Preparation Products And Raw materials

Raw materials

Preparation Products

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1271930-15-4, Cinacalcet Impurity DRelated Search:

N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanaMide (αR)-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl)propyl]-1-napthaleneMethanaMine-N-oxide 1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-, hydrochloride (1:1), (αR)- 1-(7,8-dihydronaphthalen-1-yl)ethan-1-amine hydrochloride Cinacalcene Impurity I Cinacalcet impurity C Cinacalcet Impurity 22 N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide Cinacalcet Impurity 21 (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoroMethyl)phenyl)propan-1-aMine Cinacalcet IMpurity 6 Cinacalcet IMpurity 3 (E)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)acrylamide Cinacalcet IMpurity 9 (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(M-tolyl)propan-1-aMine N-(1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide 1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethan-1-amine hydrochloride Cinacalcet Impurity H

1-NaphthaleneMethanaMine, α-Methyl-N,N-bis[3-[3-(trifluoroMethyl)phenyl]propyl]-, (αR)-

(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propan-1-amine

N-[(3-Trifluoromethyl)phenyl)propyl] Cinacalcet

N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]-N-[3-[3-(trifluoromethyl)phenyl]propyl]propan-1-amine

Cinacalcet Impurity D HCL

Cinacalcet USP RC B

Cinacalcet Impurity 5(Cinacalcet USP RC B)

"(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)

Cinacalcet USP Related Compound B

Cinacalcet impurity 20/(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propan-1-amine hydrochloride

[(1R)-1-(naphthalen-1-yl)ethyl]bis({3-[3-(trifluoromethyl)phenyl]propyl})amine

(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(2-(trifluoromethyl)phenyl)propan-1-amine hydrochloride

(R)-(1-naphthalen-1-ylethyl)-N,N-bis[3-(3-trifluoromethylphenyl)propyl]amine, hydrogen chloride

Cinacalcet Hydrochloride iMpuritX

Cinacalcet Related Compund B (Cinacalcet Impurity D)

Cinacalcet Impurity DQ: What is Cinacalcet Impurity D Q: What is the CAS Number of Cinacalcet Impurity D Q: What is the storage condition of Cinacalcet Impurity D Q: What are the applications of Cinacalcet Impurity D

Cinacalcet tertiary amine

CicalcetImpurityDHCl

CicalcetImpurity1HCl

1-Naphthalenemethanamine, α-methyl-N,N-bis[3-[3-(trifluoromethyl)phenyl]propyl]-, (αR)-

Cinacalcet Impurity D

cinacalcet iMpurity 8

1271930-15-4

C32H31F6N