(+/-)-EvodiaMine Property

Melting point:

272°C(lit.)

Boiling point:

575.1±50.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

0-10°C

solubility 

very slightly in Acetone

form 

powder to crystal

pka

17.27±0.20(Predicted)

color 

White to Orange to Green

λmax

268nm(EtOH)(lit.)

Safety

HS Code 

2939.80.0000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(+/-)-EvodiaMine Chemical Properties,Usage,Production

Description

Evodiamine is extracted and isolated from the fruit of Evodiarutaecarpa (Juss.) Benth., a rutaceae plant. It is converted into Isoevodiamine after being boiled with hydrochloric acid alcohol solution.

Definition

ChEBI: LSM-6483 is a member of beta-carbolines.

Pharmacokinetics

1. Antitumor activity
Evodiamine can inhibit the proliferation of various tumor cells, including cervical cancer, colon cancer, lung cancer, melanoma, T lymphocyte-like leukemia, prostate cancer Inhibition of proliferation of various tumor cells including cancer and breast cancer.
2. Anti-senile dementia effect

3. Effects on endocrine system
Evodiamine can inhibit 3β-hydroxysteroid dehydrogenase by reducing the activity of intracellular cyclic adenosine monophosphate (cAMP) related pathways (3β-HSD) and other steroid hormone production-related enzymes, reduce and affect the expression of signal transduction and RNA activation protein (StAR), and directly act on rat adrenal cortex reticulum cells to inhibit the secretion of corticosterone.
4. Weight loss and hypoglycemic effect
5.Anti-inflammatory and analgesic effect

6. Effects on the cardiovascular system