AVE 0991 (sodiuM salt)
- Product Name
- AVE 0991 (sodiuM salt)
- CAS No.
- 306288-04-0
- Chemical Name
- AVE 0991 (sodiuM salt)
- Synonyms
- AVE 0991 Sodium;AVE0991.Na salt;AVE 0991 (sodiuM salt);ethylcarbamoyl-[3-[4-[(5-formyl-4-methoxy-2-phenylimidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylazanide;N-[(Ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide monosodium salt
- CBNumber
- CB62677071
- Molecular Formula
- C29H33N4NaO5S2
- Formula Weight
- 604.72
- MOL File
- 306288-04-0.mol
AVE 0991 (sodiuM salt) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- color
- White to yellow
N-Bromosuccinimide Price
- Product number
- B1213
- Product name
- AVE0991sodiumsalt
- Packaging
- 2mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- CS-1753
- Product name
- AVE0991(sodiumsalt)
- Purity
- 98.42%
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- B1213
- Product name
- AVE0991sodiumsalt
- Packaging
- 5mg
- Price
- $366
- Updated
- 2021/12/16
- Product number
- CS-1753
- Product name
- AVE0991(sodiumsalt)
- Purity
- 98.42%
- Packaging
- 10mg
- Price
- $456
- Updated
- 2021/12/16
- Product number
- B1213
- Product name
- AVE0991sodiumsalt
- Packaging
- 10mg
- Price
- $557
- Updated
- 2021/12/16
AVE 0991 (sodiuM salt) Chemical Properties,Usage,Production
Biological Activity
angiotensin-(1–7) (ang-[1–7]) acts as a crucial component of the renin-angiotensin system which can regulate and maintain the blood pressure by offsetting effects of ang ii, a typical vasoconstrictor in vivo. ave 0991, a nonpeptide mimic of ang-(1–7), performs as an agonist of angiotensin-(1-7) receptor. it plays an important role in exploring effects of ang-(1-7) and evaluating the potential of ang-(1-7) as a cardiovascular drug. [1]
in vitro
ave 0991 was found to compete with ang-(1-7) for bovine aortic endothelial cell membrane receptors with an ic50 of 21±35 nm. there was no significant difference in peak concentrations of no and o2- released from ave 0991 treated group and ang-(1-7) treated group. however, the released amount of no was approximately 5 times higher in ave 0991 group than that in ang-(1-7) group. moreover, ave 0091 significantly displaced the binding of i-ang-(1-7) in both mas-transfected monkey kidney cells (cos) and mas-transfected chinese hamster ovary (cho) cells. [1]
in vivo
ave 0091 at a dosage of 0.58 nmol/g resulted in a significant decrease in urinary volume, together with an increase in urinary osmolality in water-loaded c57bl/6 mice. [2] the antidiuretic effect of ave was completely offset by the ang ii antagonists, which indicting a high specificity of ave 0991. since ang ii induced atherogenesis and ang-(1–7) offset ang ii action, it was proved that ave 0991 blocked atherogenesis in apolipoprotein e (apoe)-knockout mice model. [3]
target
IC50: 21±35 nM (Ang-(1-7) receptor)
IC 50
ave 0991 and ang-(1–7) competitively bind to bovine aortic endothelial cell membranes with ic50 values of 21 ± 35 and 220 ± 280 nm, respectively.
References
[1]wiemer g, dobrucki lw, louka fr, malinski t, heitsch h. ave 0991, a nonpeptide mimic of the effects of angiotensin-(1–7) on the endothelium. hypertension. 2002 dec; 40: 847-52.
[2] pinheiro sv, silva ac, sampaio wo, paula rd, mendes ep, bontempo ed, pesquero jb, walther t, alenina n, bader m, bleich m and santos ra. nonpeptide ave 0991 is an angiotensin-(1-7) receptor mas agonist in the mouse kidney. hypertension. 2004 oct; 44(4):490-6.
[3]toton-zuranska j, gajda m, pyka-fosciak g, kus k, pawlowska m, niepsuj a, wolkow p, olszanecki r, jawien j and korbut r. ave 0991- angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoe-knockout mice. j physiol pharm. 2010, 61(2):181-183.
AVE 0991 (sodiuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
AVE 0991 (sodiuM salt) Suppliers
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 021-61998551 13122364865
- sale1@shzysw.net
- Country
- China
- ProdList
- 9772
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 18964309092 18964309092
- 2769493375@qq.com
- Country
- China
- ProdList
- 2634
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- +86-25-58227606 +86-15305155328
- sales@dogechemical.com
- Country
- China
- ProdList
- 4128
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- kexianxun@gmail.com
- Country
- China
- ProdList
- 1037
- Advantage
- 50
- Tel
- --
- Fax
- --
- market@xlswkj.com
- Country
- CHINA
- ProdList
- 6793
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58