ChemicalBook > CAS DataBase List > MeriMepodib, VI-21497, VX-497

MeriMepodib, VI-21497, VX-497

Product Name
MeriMepodib, VI-21497, VX-497
CAS No.
198821-22-6
Chemical Name
MeriMepodib, VI-21497, VX-497
Synonyms
VI 21497;MeriMepodib, VI-21497, VX-497;MERIMEPODIB; VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497;(S)-Tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate;HCV,Inhibitor,Merimepodib,HBV,Hepatitis C virus,Hepatitis B virus,VX497,VX 497,inhibit,MMPD;[(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate;[[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]carbamic acid (3S)-tetrahydro-3-furanyl ester;Carbamic acid, N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-, (3S)-tetrahydro-3-furanyl ester
CBNumber
CB62680808
Molecular Formula
C23H24N4O6
Formula Weight
452.46
MOL File
198821-22-6.mol
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MeriMepodib, VI-21497, VX-497 Property

Boiling point:
571.4±50.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
≥45.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
11.66±0.46(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29351
Product name
Merimepodib
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29351
Product name
Merimepodib
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
29351
Product name
Merimepodib
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
29351
Product name
Merimepodib
Packaging
10mg
Price
$243
Updated
2024/03/01
ApexBio Technology
Product number
B1112
Product name
Merimepodib
Packaging
5mg
Price
$326
Updated
2021/12/16
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MeriMepodib, VI-21497, VX-497 Chemical Properties,Usage,Production

Description

Merimepodib is an inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Kis = 7 and 10 nM for IMPDH type I and type II, respectively) with antiviral and immunosuppressant activities. It reduces Ebola, Lassa, chikungunya, Junin, and Zika virus titers in vitro and inhibits Zika virus replication in Huh7 cells (EC50 = 0.6 μM). Merimepodib inhibits the proliferation of PHA-stimulated T cells and SPAS-stimulated B cells (IC50s = 104 and 132 nM, respectively), effects that can be reversed by guanosine but not adenosine . In vivo, merimepodib (50 and 100 mg/kg) increases allograft survival in a murine skin transplantation model and prevents development of graft versus host disease (GVHD) in splenocyte allografted mice.

Uses

Inhibition of inosine monophosphate dehydrogenase (IMPDH), which has potential antiviral, antiproliferative, antiparasitic, and immunosuppressive activity.

in vitro

vx-497 (mw 452.5) inhibited the proliferation of primary human, rat, mouse, and dog lymphocytes at concentrations of approximately 100 nm. the inhibitory effect of vx-497 on lymphocytes was reversed in the presence of exogenous guanosine, but not in the presence of adenosine or uridine, confirming that the antilymphocytic activity of vx-497 was specifically due to inhibition of impdh[1]. vx-497 was most potent against the first group of viruses on virus replication, which included hbv, hcmv, emcv, and rsv, with ic50 values of 0.38, 0.80, 1.0, and 1.14 μm, respectively [3].

in vivo

oral administration of vx-497 dose-dependently inhibited the primary igm antibody response, with an ed50 value of approximately 30-35 mg/kg in mice. single daily dosing of vx-497 was as effective as twice-daily dosing in this model of immune activation [1].in the skin transplant study, trunk skin grafts from balb/c mice were grafted onto c57bl/6 mice. administration of vx-497 twice daily until day 10 significantly prolonged graft survival to 13.2 ± 1.2 (p < 0.001, kaplan meier log-rank test) days in the 50 mg/kg group and 13.9 ± 1.0 (p < 0.001) days in the 85 mg/kg group [4].

References

[1]. jain j1, almquist sj,shlyakhter d,harding mw. vx-497: a novel, selective impdh inhibitor and immunosuppressive agent.j pharm sci.2001 may;90(5):625-37.
[2]. pimkin m1,markham gd. inosine 5'-monophosphate dehydrogenase.adv enzymol relat areas mol biol.2009;76:1-53.
[3]. markland w1,mcquaid tj,jain j,kwong ad. broad-spectrum antiviral activity of the imp dehydrogenase inhibitor vx-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon.antimicrob agents chemother.2000 apr;44(4):859-66.
[4]. decker cj1,heiser ad,chaturvedi pr,faust tj,ku g,moseley s,nimmesgern e. the novel impdh inhibitor vx-497 prolongs skin graft survival and improves graft versus host disease in mice.drugs exp clin res.2001;27(3):89-95.

MeriMepodib, VI-21497, VX-497 Preparation Products And Raw materials

Raw materials

Preparation Products

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MeriMepodib, VI-21497, VX-497 Suppliers

China 61 India 1 United Kingdom 1 United States 10 Global 73
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
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58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
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7552
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Cool Pharm, Ltd
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021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
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12346
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58
LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
Email
sales@letopharm.com
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China
ProdList
2384
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4566
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55
Hangzhou Cheminspire Technology Co., Ltd.
Tel
0571-89081561; 10006559855
Fax
0571 89081561
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info@cheminspire.com
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China
ProdList
412
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Shanghai Beckham Medical Technology Co., Ltd
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021-13816613772 13816613772
Fax
QQ: 12922499
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huahero21@sina.com
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China
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BOC Sciences
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16314854226
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info@bocsci.com
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United States
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9923
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Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
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58
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
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27313
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View Lastest Price from MeriMepodib, VI-21497, VX-497 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Merimepodib 198821-22-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Merimepodib 198821-22-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
MeriMepodib, VI-21497, VX-497 198821-22-6
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

198821-22-6, MeriMepodib, VI-21497, VX-497Related Search:


  • MeriMepodib, VI-21497, VX-497
  • [[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]carbamic acid (3S)-tetrahydro-3-furanyl ester
  • VI 21497
  • Carbamic acid, N-[[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl]-, (3S)-tetrahydro-3-furanyl ester
  • [(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate
  • MERIMEPODIB; VX497; VX-497; VX 497; MMP; VI21497; VI-21497; VI 21497
  • (S)-Tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate
  • HCV,Inhibitor,Merimepodib,HBV,Hepatitis C virus,Hepatitis B virus,VX497,VX 497,inhibit,MMPD
  • 198821-22-6