ChemicalBook > CAS DataBase List > Inauhzin
Inauhzin
- Product Name
- Inauhzin
- CAS No.
- 309271-94-1
- Chemical Name
- Inauhzin
- Synonyms
- INZ;CS-1439;Inauhzin;Chlormax;Inauhzin(INZ);Inauhzin, >=98%;10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine;"1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one";2-(9H-[1,2,4]TRIAZINO[6,5-B]INDOL-3-YLTHIO)-1-(10H-PHENOTHIAZIN-10-YL)BUTAN-1-ONE;1-Butanone, 1-(10H-phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)-
- CBNumber
- CB62681971
- Molecular Formula
- C25H19N5OS2
- Formula Weight
- 469.58
- MOL File
- 309271-94-1.mol
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Inauhzin Property
- Boiling point:
- 773.6±70.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥23.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 10.24±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19771
- Product name
- Inauhzin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19771
- Product name
- Inauhzin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19771
- Product name
- Inauhzin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
TRC
- Product number
- P318090
- Product name
- 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one(Inauhzin)
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B3272
- Product name
- Inauhzin
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $110
- Updated
- 2021/12/16
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Inauhzin Chemical Properties,Usage,Production
Uses
Inauhzin acts as an inhibitor of SIRT1 activity, and also activates p53 resulting in a decrease in tumor growth.
Biological Activity
inauhzin is a small-molecule inhibitor of sirt1 with ic50 value of 0.7-2μm [1].inauhzin inhibits sirt1 deacetylation activity and subsequently activates the substrate of sirt1, p53, in a dose-dependent manner. it shows an induction of acetylation of p53 and histone h3 in the k382 and k9 residues, respectively. the inhibition of sirt1 is selective. it has no significant effect on sirt2, sirt3 or hdac8 in the fluor-de-lys fluorimetric assay. since it is an activator of p53, inauhzin inhibits cell growth in different p53-containing human cancer cells including h460, h1299, a549, ht29 and wi38. the ic50 values are 5.4μm, 51.9μm, 3.2μm, 33.9μm and 85.4μm, respectively. furthermore, inauhzin induces cell apoptosis through activating p53. in the xenograft tumours derived from h460 cells, inauhzin also significantly induces p53 activity and p53-dependent apoptosis at 2μm [1].
References
[1] zhang q, zeng sx, zhang y, zhang y, ding d, ye q, meroueh so, lu h. a small molecule inauhzin inhibits sirt1 activity and suppresses tumour growth through activation of p53. embo mol med. 2012 apr;4(4):298-312.
Inauhzin Preparation Products And Raw materials
Raw materials
Preparation Products
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