ABT-333

ChemicalBook > CAS DataBase List > ABT-333

Product Name: ABT-333
CAS No.: 1132935-63-7
Chemical Name: ABT-333
Synonyms: CS-2000;ABT-333;Dasabuvir;ABT333; ABT 333;ABT-333/Dasabuvir;Dasabuvir (ABT-333);Dasabuvir-13C 15N2 D3;N-{6-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]-2-naphthyl}methanesulfonamide;Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-;N-[6-[3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Dasabuvir (ABT-333)
CBNumber: CB62681991
Molecular Formula: C26H27N3O5S
Formula Weight: 493.57
MOL File: 1132935-63-7.mol

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ABT-333 Property

Melting point:: >192oC (dec.)
Density: 1.317±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
pka: 8.52±0.30(Predicted)
form: Solid
color: Pale Brown to Light Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18482
Product name: ABT-333
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18482
Product name: ABT-333
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 18482
Product name: ABT-333
Purity: ≥98%
Packaging: 25mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 18482
Product name: ABT-333
Purity: ≥98%
Packaging: 50mg
Price: $235
Updated: 2024/03/01

TRC

Product number: D193550
Product name: Dasabuvir
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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ABT-333 Chemical Properties,Usage,Production

Uses

Dasabuvir is an antiviral drug used in the treatment of chronic hepatitis C virus (HCV) infection.

Definition

ChEBI: A member of the class of pyrimidone, which is (as the monohydrate of its sodium salt) in combination with ombitasvir, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as c rrhosis of the liver.

Clinical Use

Treatment of chronic hepatitis C infection

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: avoid concomitant use with clarithromycin and telithromycin; concentration possibly reduced by rifampicin - avoid.
Antidepressants: concentration possibly reduced by St John’s wort - avoid.
Antiepileptics: concentration reduced by carbamazepine - avoid; concentration possibly reduced by fosphenytoin, phenobarbital, phenytoin and primidone - avoid.
Antifungals: concentration of both drugs increased with ketoconazole and possibly itraconazole and posaconazole - avoid.
Diuretics: concentration of furosemide increased (reduce furosemide dose).
Immunosuppressants: increases concentration of ciclosporin (reduce ciclosporin dose by a fifth); everolimus (avoid); sirolimus and tacrolimus (reduce dose and use only if benefit outweighs risk - see SPC).
Lipid-regulating drugs: avoid with atorvastatin, gemfibrozil and simvastatin; concentration of rosuvastatin increased (reduce dose of rosuvastatin).
Oestrogens: avoid concomitant use with ethinylestradiol.

Metabolism

Dasabuvir is mainly metabolised by CYP2C8 and to a lesser extent by CYP3A. Seven metabolites were identified in plasma. The most abundant plasma metabolite was M1, which represented 21% of drugrelated radioactivity (AUC) in circulation following single dose; it is formed via oxidative metabolism predominantly by CYP2C8.
Following a 400 mg 14C-dasabuvir dose, approximately 94% of the radioactivity was recovered in faeces with limited radioactivity (approximately 2%) in urine. Unchanged dasabuvir accounted for 26.2% and M1 for 31.5% of the total dose in faeces. M1 is mainly cleared through direct biliary excretion with the contribution of UGT-mediated glucuronidation and, to a small extent, oxidative metabolism.

ABT-333 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT-333 Suppliers

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View Lastest Price from ABT-333 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Dasabuvir 1132935-63-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-04

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Abt333 1132935-63-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-10-16

Zhuozhou Wenxi import and Export Co., Ltd

Product: dasabuvir 1132935-63-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

1132935-63-7, ABT-333Related Search:

ABT-333

Dasabuvir (ABT-333)

N-[6-[3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Dasabuvir (ABT-333)

Dasabuvir

ABT-333/Dasabuvir

N-{6-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]-2-naphthyl}methanesulfonamide

CS-2000

ABT333; ABT 333

Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-

Dasabuvir-13C 15N2 D3

1132935-63-7

132935-63-7