CEP-37440

Product Name: CEP-37440
CAS No.: 1391712-60-9
Chemical Name: CEP-37440
Synonyms: CS-1603;CEP-37440;CEP37440;CEP 37440;2-(5-chloro-2-{(S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ylamino}pyrimidin-4-ylamino)-N-methylbenzamide;(S)-2-((5-chloro-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide;2-[(5-chloro-2-{[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino}pyrimidin-4-yl)amino]-N-methylbenzamide;2-[[5-Chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide;Benzamide, 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-;inhibit,Inhibitor,Cluster of differentiation 246,PTK2,triple-negative breast cancer,inflammatory breast cancer,CEP-37440,Anaplastic lymphoma kinase,FAK1,Anaplastic lymphoma kinase (ALK),Focal adhesion kinase,CEP 37440,PTK2 protein tyrosine kinase 2,autophosphorylation kinase,CD246,FAK,ALK tyrosine kinase receptor
CBNumber: CB62685924
Molecular Formula: C30H38ClN7O3
Formula Weight: 580.12
MOL File: 1391712-60-9.mol

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CEP-37440 Property

Density: 1.300±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMF: 12 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
form: A crystalline solid
pka: 14.57±0.46(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21278
Product name: CEP-37440
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 21278
Product name: CEP-37440
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 21278
Product name: CEP-37440
Purity: ≥98%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 21278
Product name: CEP-37440
Purity: ≥98%
Packaging: 25mg
Price: $469
Updated: 2024/03/01

TRC

Product number: C256690
Product name: CEP-37440
Packaging: 5mg
Price: $520
Updated: 2021/12/16

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CEP-37440 Chemical Properties,Usage,Production

Uses

CEP-37440 is a highly potent, selective and orally active inhibitor of ALK.

in vivo

CEP-37440 (3-55 mg/kg; p.o.; b.i.d and q.d., for 12 d) inhibits breast tumor growth in Sup-M2 xenograftin SCID mice^[2].
CEP-37440 (30 mg/kg; p.o; once, for 24 h) inhibits tyrosine phosphorylation in Sup-M2 xenografts mice^[2].
CEP-37440 (55 mg/kg; p.o; once, for 24 h) inhibits FAK phosphorylation in CWR22 xenografts in Nude mice^[2].
CEP-37440 (1-10 mg/kg; p.o and i.v.; CD-1 mouse, Sprague-Dawley (SD) rats) has good pharmacokinetic parameters^[2].

Pharmacokinetic parameters in CD-1 mouse and Sprague-Dawley (SD) rats^[2]

	PK parameter	CD-1 mouse	SD rat
iv	dose (mg/kg)	1	1
iv	t_1/2 (h)	3.0	2
iv	AUC_0-∞ (ng*h/mL)	1612	4005
iv	Vd (L/kg)	2.7	0.8
iv	CL (mL/min/kg)	10	4
po	dose (mg/kg)	10	5
po	C_max (ng/mL)	1533	1340

Animal Model:	SCID/Beige with Sup-M2 xenografts^[2]
Dosage:	3 mg/kg (b.i.d), 10 mg/kg (b.i.d), 30 mg/kg (b.i.d and q.d. ), and 55 mg/kg (q.d.)
Administration:	Oral administration; b.i.d and q.d., for 12 days
Result:	Inhibited tumor growth in a dose-dependent manner.

Animal Model:	SCID/Beige with Sup-M2 xenografts and Nu/Nu mice female with Sup-M2 xenografts^[2]
Dosage:	30 mg/kg
Administration:	Oral administration; once, for 24 hours
Result:	Decreased NPM-ALK phosphorylation (>85%).

Animal Model:	Nu/Nu mice female with CWR22 xenografts^[2]
Dosage:	55 mg/kg
Administration:	Oral administration; once, for 24 hours
Result:	Inhibited FAK phosphorylation in a time-dependent manner.

CEP-37440 Preparation Products And Raw materials

Raw materials

Preparation Products

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CEP-37440 Suppliers

China 57 India 1 United States 9 Global 67

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

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View Lastest Price from CEP-37440 manufacturers

Career Henan Chemical Co

Product: CEP-37440 1391712-60-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2019-12-31

1391712-60-9, CEP-37440Related Search:

CEP-37440

2-[[5-Chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

2-(5-chloro-2-{(S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ylamino}pyrimidin-4-ylamino)-N-methylbenzamide

(S)-2-((5-chloro-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

CEP37440;CEP 37440

CS-1603

Benzamide, 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-

inhibit,Inhibitor,Cluster of differentiation 246,PTK2,triple-negative breast cancer,inflammatory breast cancer,CEP-37440,Anaplastic lymphoma kinase,FAK1,Anaplastic lymphoma kinase (ALK),Focal adhesion kinase,CEP 37440,PTK2 protein tyrosine kinase 2,autophosphorylation kinase,CD246,FAK,ALK tyrosine kinase receptor

2-[(5-chloro-2-{[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino}pyrimidin-4-yl)amino]-N-methylbenzamide

1391712-60-9

C30H38ClN7O3

Inhibitors