3-Bromo-5-methyl-benzene-1,2-diamine
- Product Name
- 3-Bromo-5-methyl-benzene-1,2-diamine
- CAS No.
- 70733-25-4
- Chemical Name
- 3-Bromo-5-methyl-benzene-1,2-diamine
- Synonyms
- 3-bromo-5-methylo-phenylenediamine;3-Bromo-5-methyl-benzene-1,2-diamine;1,2-Benzenediamine, 3-bromo-5-methyl-;3-Bromo-5-methylphenylene-1,2-diamine, 3-Bromo-4,5-diaminotoluene
- CBNumber
- CB62692557
- Molecular Formula
- C7H9BrN2
- Formula Weight
- 201.06
- MOL File
- 70733-25-4.mol
3-Bromo-5-methyl-benzene-1,2-diamine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder
- color
- Brown to dark brown
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8496AE
- Product name
- 3-Bromo-5-methyl-benzene-1,2-diamine
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 3730-9-X7
- Product name
- 3-Bromo-5-methylbenzene-1,2-diamine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 3730-9-X7
- Product name
- 3-Bromo-5-methylbenzene-1,2-diamine
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 087959
- Product name
- 3-Bromo-5-methyl-benzene-1,2-diamine
- Packaging
- 1g
- Price
- $536
- Updated
- 2021/12/16
- Product number
- 3730-9-X7
- Product name
- 3-Bromo-5-methylbenzene-1,2-diamine
- Packaging
- 5G
- Price
- $952
- Updated
- 2021/12/16
3-Bromo-5-methyl-benzene-1,2-diamine Chemical Properties,Usage,Production
Synthesis
827-24-7
70733-25-4
General procedure for the synthesis of 3-bromo-5-toluene-1,2-diamine from 2-bromo-4-methyl-6-nitroaniline: 2-bromo-4-methyl-6-nitroaniline (5.00 g, 21.64 mmol) was dissolved in a solvent mixture of methanol (148 mL) and tetrahydrofuran (18.50 mL). Ammonium chloride (23.15 g, 433 mmol) was added to the solution followed by zinc powder (14.15 g, 216 mmol). The reaction mixture was heated to 40 °C and maintained at this temperature for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The concentrate was redissolved in a mixture of ethyl acetate and saturated aqueous sodium carbonate solution with vigorous stirring for 10 minutes. The reaction mixture was filtered through a sintered glass funnel and the solid residue was washed with additional ethyl acetate. The organic layer was separated and washed sequentially twice with water, once with saturated saline and then dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the intermediate 3-bromo-5-toluene-1,2-diamine (4.35 g, 21.63 mmol, 100% yield). The product was confirmed by 1H NMR (400 MHz, chloroform-d) and LC-MS (Method H, RT = 0.93 min, MS (ESI) m/z: 201.0 [M + H]+) characterization.
References
[1] Patent: WO2018/13776, 2018, A1. Location in patent: Page/Page column 98
[2] Patent: WO2018/13774, 2018, A1. Location in patent: Page/Page column 139
[3] Organic Letters, 2006, vol. 8, # 22, p. 4989 - 4992
[4] Chemische Berichte, 1890, vol. 23, p. 1044
3-Bromo-5-methyl-benzene-1,2-diamine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-5-methyl-benzene-1,2-diamine Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0510-0510-86396359 13382276200
- sales@jalor-chem.com
- Country
- China
- ProdList
- 996
- Advantage
- 56
- Tel
- 0519-85252752 15366845260
- Fax
- 86-0519-85683352
- taihuaren@vip.163.com
- Country
- China
- ProdList
- 1124
- Advantage
- 58
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 0711-3617768 13308685235
- Fax
- 0711-3616558
- lihongcai4360@sina.com
- Country
- China
- ProdList
- 1510
- Advantage
- 55
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 0512-87819718 18912655635
- 2587879032@qq.com
- Country
- China
- ProdList
- 1401
- Advantage
- 58