PF 06465469 Discontinued See A191400
- Product Name
- PF 06465469 Discontinued See A191400
- CAS No.
- 1407966-77-1
- Chemical Name
- PF 06465469 Discontinued See A191400
- Synonyms
- PF 06465469;PF06465469,PF 06465469;PF 06465469 Discontinued See A191400;(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide;3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide;(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide;(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide;3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide;Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-
- CBNumber
- CB62694359
- Molecular Formula
- C30H33N7O2
- Formula Weight
- 523.63
- MOL File
- 1407966-77-1.mol
PF 06465469 Discontinued See A191400 Property
- Melting point:
- 209-212°C
- Boiling point:
- 730.2±60.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear
- pka
- 12.83±0.70(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PZ0209
- Product name
- PF-06465469
- Purity
- ≥97% (HPLC)
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- PZ0209
- Product name
- PF-06465469
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $496
- Updated
- 2024/03/01
- Product number
- 4710
- Product name
- PF06465469
- Purity
- ≥95%(HPLC)
- Packaging
- 10
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 4710
- Product name
- PF06465469
- Purity
- ≥95%(HPLC)
- Packaging
- 50
- Price
- $1208
- Updated
- 2021/12/16
- Product number
- A191400
- Product name
- (R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide
- Packaging
- 2.5mg
- Price
- $385
- Updated
- 2021/12/16
PF 06465469 Discontinued See A191400 Chemical Properties,Usage,Production
Chemical Properties
Beige Solid
Uses
PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay.
Uses
(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk). Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc.
storage
Store at +4°C