5-bromo-3-chloropyrazin-2-ol

Product Name: 5-bromo-3-chloropyrazin-2-ol
CAS No.: 21943-17-9
Chemical Name: 5-bromo-3-chloropyrazin-2-ol
Synonyms: 5-bromo-3-chloropyrazin-2-ol;5-Bromo-3-chloro-2(1H)-pyrazinone;5-Bromo-3-chloropyrazin-2(1H)-one;5-bromo-3-chloro-1H-pyrazin-2-one;2-Hydroxy-3-chloro-5-bromopyrazine;5-bromo-3-chloro-2-hydroxypyrazine;2(1H)-Pyrazinone, 5-bromo-3-chloro-
CBNumber: CB62703642
Molecular Formula: C4H2BrClN2O
Formula Weight: 209.43
MOL File: 21943-17-9.mol

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5-bromo-3-chloropyrazin-2-ol Property

Density: 2.16±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.35±0.60(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C4H2BrClN2O/c5-2-1-7-4(9)3(6)8-2/h1H,(H,7,9)
InChIKey: AUPTWKVUAKJWMG-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)N=C1Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B415853
Product name: 5-Bromo-3-chloropyrazin-2-ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B415853
Product name: 5-Bromo-3-chloropyrazin-2-ol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 2431EG
Product name: 5-Bromo-3-chloropyrazin-2(1H)-one
Packaging: 250mg
Price: $104
Updated: 2021/12/16

AK Scientific

Product number: 2431EG
Product name: 5-Bromo-3-chloropyrazin-2(1H)-one
Packaging: 10g
Price: $597
Updated: 2021/12/16

Ambeed

Product number: A109822
Product name: 5-Bromo-3-chloropyrazin-2(1H)-one
Purity: 97%
Packaging: 5g
Price: $74
Updated: 2021/12/16

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5-bromo-3-chloropyrazin-2-ol Chemical Properties,Usage,Production

Synthesis

21943-13-5

21943-17-9

General procedure for the synthesis of 5-bromo-3-chloropyrazin-2-one from 5-bromo-3-chloropyrazin-2-amine: 5-bromo-3-chloropyrazin-2-amine (9.00 g, 43.2 mmol) was dissolved in concentrated sulfuric acid (35 mL) at 0 °C and added slowly and dropwise to a pre-prepared sodium nitrite (3.52 g, 51.0 mmol) concentrated sulfuric acid (20 mL ) solution. The reaction mixture was heated at 40°C for 1 hr, then cooled to room temperature and slowly poured into crushed ice (400 mL) to quench the reaction. The reaction mixture was extracted with ethyl acetate (200 mL), the organic phase was dried over anhydrous sodium sulfate and filtered, and concentrated under reduced pressure to afford the target product 5-bromo-3-chloropyrazin-2(1H)-one (6.13 g, 68% yield) as a brown solid. The product characterization data were as follows: melting point 175-177 °C; IR spectra (νmax/cm-1) 3019 (Ar-H), 1653 (C=O); NMR hydrogen spectrum (500 MHz, CD3OD) δH 7.72 (1H, s, 6-H); NMR carbon spectra (125 MHz, CDCl3) δC 114.2, 127.6, 146.4, 154.0; liquid chromatography-mass spectrometry (LC-MS, 6 min) m/z 213, 211, 209 ([M+H]+); high-performance liquid chromatography (HPLC) retention time (tR) 2.54 min, purity >99%; high-resolution mass spectrometry (HRMS) measured values: [M+H]+ m/z 208.9113, calculated value 208.9112.

References

[1] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728,16
[2] Tetrahedron, 2012, vol. 68, # 47, p. 9713 - 9728

5-bromo-3-chloropyrazin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-3-chloropyrazin-2-ol Suppliers

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21943-17-9, 5-bromo-3-chloropyrazin-2-olRelated Search:

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21943-17-9