5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester
- Product Name
- 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester
- CAS No.
- 301359-45-5
- Chemical Name
- 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester
- Synonyms
- Ethyl 4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester
- CBNumber
- CB62706173
- Molecular Formula
- C14H15ClN2O2S
- Formula Weight
- 310.8
- MOL File
- 301359-45-5.mol
5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester Property
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 9101CJ
- Product name
- Ethyl4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 301359455
- Product name
- Ethyl4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CM252042
- Product name
- Ethyl4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CM252042
- Product name
- Ethyl4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $561
- Updated
- 2021/12/16
- Product number
- CD11151027
- Product name
- Ethyl4-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $594
- Updated
- 2021/12/16
5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester Chemical Properties,Usage,Production
Synthesis
141-97-9
89-98-5
17356-08-0
301359-45-5
General procedure: o-chlorobenzaldehyde (1 mmol), ethyl acetoacetate (1 mmol; 0.132 g) and thiourea (1.5 mmol; 0.114 g) were added in a round bottom flask, followed by the addition of nanomaterials of silica disulfate (NMSDSA) (10 mol%; 0.024 g) or nanomaterials of silica monosulfate sodium salt (NMSMSA) (10 mol%; 0.018 g) as catalysts. The reaction mixtures were stirred without magnetic stirring at 80 °C under solvent-free conditions. The reaction progress was monitored by TLC (unfolding agent: hexane/ethyl acetate, 5:2). Upon completion of the reaction, ethyl acetate (10 mL) was added to the mixture, stirred and refluxed for 5 min, followed by washing with water (10 mL). The aqueous and organic phases were separated by decantation (the reaction product was soluble in hot ethyl acetate, while the NMSDSA or NMSMSA catalyst was soluble in water). The solvent in the organic phase was evaporated and the crude product was purified by recrystallization from ethanol/water (10:1) to give ethyl 4-(2-chlorophenyl)-6-methyl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylate.
References
[1] Synthetic Communications, 2013, vol. 43, # 11, p. 1477 - 1483
[2] Chinese Journal of Chemistry, 2011, vol. 29, # 9, p. 1863 - 1868
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007, vol. 46, # 12, p. 2045 - 2048
[4] Synthetic Communications, 2009, vol. 39, # 5, p. 880 - 886
[5] Tetrahedron Letters, 2009, vol. 50, # 24, p. 2889 - 2892
5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester manufacturers
- Product
- 5-PyriMidinecarboxylic acid,4-(2-chlorophenyl)-1,2,3,4-tetrahydro-6-Methyl-2-thioxo-, ethyl ester 301359-45-5
- Price
- US $100.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2018-07-23